Methods of therapeutic treatment with N-(3-ouinuclidinyl)-2-hydr

Details Methods of therapeutic treatment with N-(3-ouinuclidinyl)-2-hydr Methods of therapeutic treatment with N-(3-ouinuclidinyl)-2-hydr

1990-12-24

1992-01-28

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3144

Patent

active

050844601

ABSTRACT:
This invention provides 3-quinuclidinyl benzamides which in the form of pharmaceutical compositions have utility as therapeutic agents which exhibit anxiolytic antipsychotic and cognitive improving effects in warm blooded animals.
Illustrative of an invention compound is N-(1-azabicyclo[2.2.2]oct-3-yl)-5-chloro-4-dimethylamino-2-hydroxythiobenz amide: ##STR1## or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4593034 (1986-06-01), Munson et al.
patent: 4657911 (1987-04-01), Imbert et al.
E. E. Mikhlina, et al. Khim.-Farm. Zh. 1973, 7(8) 20-24 (CA 79:146358A, Pharmdoc 32658N abstract).

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