Methods of synthesizing olanzapine

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

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Reexamination Certificate

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07425627

ABSTRACT:
This invention encompasses methods of synthesizing olanzapine without solvents or by using low boiling organic solvents.

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Calligaro, D.O., et al., “The synthesis and biological activity of some known and putative metabolites of the atypical antipsychotic agent olanzapine”Bioorganic&Medicinal Chemistry Letters, Oxford, GB, vol. 7, No. 1, Jan. 7, 1997, pp. 25-30.

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