Methods of synthesizing insulin polypeptide-oligomer...

Details Methods of synthesizing insulin polypeptide-oligomer... Methods of synthesizing insulin polypeptide-oligomer...

2008-05-06

2008-05-06

Tate, Christopher (Department: 1654)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

C514S003100, C530S303000

Reexamination Certificate

active

07368260

ABSTRACT:
Methods for synthesizing proinsulin polypeptides are described that include a contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide bond(s) capable of being cleaved to yield the insulin polypeptide with an oligomer under conditions sufficient to couple the oligomer to the insulin polypeptide portion of the proinsulin polypeptide and provide a proinsulin polypeptide-oligomer conjugate, and cleaving the one or more peptides from the proinsulin polypeptide-oligomer conjugate to provide the insulin polypeptide-oligomer conjugate. Methods of synthesizing proinsulin polypeptide-oligomer conjugates are also described as are proinsulin polypeptide-oligomer conjugates. Methods of synthesizing C-peptide polypeptide-oligomer conjugates are also described.

REFERENCES:
patent: 6913903 (2005-07-01), Soltero et al.
patent: 7166571 (2007-01-01), Soltero et al.
patent: 2003/0228652 (2003-12-01), Radhakrishnan et al.

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