Methods of synthesizing hydroxyapatite powders and bulk material

Chemistry of inorganic compounds – Phosphorus or compound thereof – Oxygen containing

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423309, 423311, 501 1, C01B 2532

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058583181

ABSTRACT:
Methods are provided for producing non-porous controlled morphology hydroxyapatite granules of less than 8 .mu.m by a spray-drying process. Solid or hollow spheres or doughnuts can be formed by controlling the volume fraction and viscosity of the slurry as well as the spray-drying conditions. Methods of providing for homogenous cellular structure hydroxyapatite granules are also provided. Pores or channels or varying size and number can be formed by varying the temperature at which a hydroxyapatite slurry formed in basic, saturated ammonium hydroxide is spray-dried. Methods of providing non-porous controlled morphology hydroxyapatite granules in ammonium hydroxide are also provided. The hydroxyapatite granules and bulk materials formed by these methods are also provided.

REFERENCES:
patent: Re35340 (1996-10-01), Ichitsuka et al.
patent: 3929971 (1975-12-01), Roy
patent: 4335086 (1982-06-01), Spencer
patent: 4371484 (1983-02-01), Inukai et al.
patent: 4752457 (1988-06-01), Toriyama et al.
patent: 4798886 (1989-01-01), Kato et al.
patent: 4849193 (1989-07-01), Palmer et al.
patent: 4874511 (1989-10-01), Kawasaki et al.
patent: 4952323 (1990-08-01), Nakabayashi et al.
patent: 5017518 (1991-05-01), Hirayama et al.
patent: 5039408 (1991-08-01), Ichitsuka et al.
patent: 5082566 (1992-01-01), Tagaya et al.
patent: 5108956 (1992-04-01), Inoue et al.
patent: 5158756 (1992-10-01), Ogawa et al.
patent: 5205928 (1993-04-01), Inoue et al.
patent: 5435822 (1995-07-01), Blouin
patent: 5441635 (1995-08-01), Ichitsuka et al.
Hohling et al., "Quantitative electron microscopic investigations of mineral nucleation in collagen" Cell Tissue Res. (1974) 148:11-26.
Posner et al. "Refinement of the hydroxyapatite structure" Acta Crystallogr. (1958) 11:308-309.
Hench, "Bioceramics: From concept to clinic" J. Am. Cer. Soc. (1991) 74:1487-1510.
Tiselius et al., "Protein chromatography on calcium phosphate columns" Arch. Biochem. Biophys. (1956) 65:132-155.
Kadoya et al., "High performance liquid chromatography of proteins on a hydroxyapatite column" Liquid Chrom. (1988) 11(14):2951-2967.
Kurtz et al., "Multihormonal induction of hepatic .alpha..sub.2u -globulin mRNA as measured by hybridization to complementary DNA" Proc. Natl. Acad. Sci. USA (1977) 74:4791-4795.
Liu et al., "Plasma-sprayed hydroxyapatite coating: effect of different calcium phosphate ceramics" J. Mater. Sci. Med. (1994) 5:147-153.
Tanahashi et al., "Fibrous hydroxyapatite grown in the gel system: effects of pH of the solution on the growth rate and morphology" J. Mater. Sci. Med. (1992) 3:48-53.
Li et al., "Process of formation of bone-like apatite layer on silica gel" J. Ater. Sci. Med. (1993) 4:127-131.
Yubao et al., "Preparation and characterization of nanograde osteoapatite-like rod crystals" J. Mater. Sci. Med. (1994) 5:252-255.
Crosby et al., "Effects of drying conditions on the properties of spray-dried particles" Chem. Eng. Prog. (1958) 54(7):56-63.
Jarcho, "Calcium phosphate ceramics as hard tissue prosthetics" Clin. Orthoped. Relat. Res. (1981) 157:259-278.
Luo et al., "Synthesis of ultrafine hydroxyapatite particles by a spray dry method" Mater. Sci. Eng. (1995) C3:75-78.
Fowler, "Infrared studies of apatites. I. Vibrational assignments for calcium, strontium, and barium hydroxyapatites utilizing isotopic substitutions" J. Inorg. Chem. (1974) 13:194-207.
Charlesworth et al., "Evaporation from drops containing dissolved solids" AIChEJ (1960) 6(1):9-23.
Kirk et al., "The effect of the calcination process on the crystallite shape of sol-gel cerium oxide used for glass polishing" J. Mater. Sci. (1995) 30:2171-2175.
Konsztowicz et al., "The role of surface tension in the formation of donut-shaped granules during spray-drying" E. Ceram. Trans. (1990) 26:46-53.
Luo et al., "Preparing hydroxyapatite powders with controlled morphology" Biomaterials (1996) 17:1959-1963.
Luo et al., "Preparation of ultrafine (nanostructured) hydroxyapatite spherical particles using spray dry method" Session S3: Mineralized Tissues, Nov. 29, 9:45 AM S3.4, p. 597.

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