Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-06-07
2011-06-07
Habte, Kahsay T (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S225200, C514S225800, C514S226200
Reexamination Certificate
active
07956183
ABSTRACT:
A method for the synthesis of a diaminophenothiazinium compound of the following formula:comprising (a) purifying a corresponding reduced compound which is N-acylated at the heterocyclic nitrogen; (b) deacylating the purified compound to provide the corresponding reduced compound; and (c) oxidizing the reduced compound to provide the diaminophenothiazinium compound. Optional purification may performed, for example, after deacylating and after oxidizing. The method provides high purity diaminophenothiazinium compounds which are suitable for pharmaceutical and related therapeutic uses. Such uses include inactivating pathogens, the treatment of the infectious diseases, and for the treatment of diseases of protein aggregation, such as tauopathies, including Alzheimer's disease.
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Baddeley Thomas Craven
Marshall Colin
Sinclair James Peter
Storey John Mervyn David
Wischik Claude Michel
Foley & Lardner LLP
Habte Kahsay T
WisTa Laboratories Ltd.
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