Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1994-08-05
2000-09-05
Chan, Christina Y.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241301, 4241411, 4241441, 4241531, 4241731, 5303871, 5303881, 5303882, 53038822, 5303887, 53038873, 53038875, A61K 39395, C07K 1628
Patent
active
061139017
ABSTRACT:
Disclosed are immunopotentiating agents, and vaccines thereof, which enhance and/or otherwise modify immune responses, and methods for their preparation and use in vivo. Immunopotentiating agents can be single agents that act directly, adjuvants added concurrently with the agents, or preferably, heteroconjugates wherein the immunopotentiating agent is chemically coupled to the compound against which an immune response is desired. Examples of immunopotentiating agents include monoclonal antibodies and proteins derived from microorganisms (e.g., enterotoxins) which activate T cells. The compounds against which an immune response can be generated, which may be the second component in a heteroconjugate, include compounds from abnormal or diseased tissues such as tumors, or infectious agents, such as viruses, bacteria, fungi, protozoal or metozoal parasites, and can be obtained by natural or recombinant means. Also disclosed is the use of monoclonal antibodies such as anti-CD3 antibodies or T cells, prepared from mammals whose immune systems have responded to administration of a heteroconjugate, in the induction of passive immunity.
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Leo, O., Foo, M.,
ARCH Development Corporation
Chan Christina Y.
Gambel Phillip
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