Methods of stimulating granulocyte-macrophage progenitor cells

Details Methods of stimulating granulocyte-macrophage progenitor cells Methods of stimulating granulocyte-macrophage progenitor cells

1994-03-07

1997-07-22

Allen, Marianne P.

Drug, bio-affecting and body treating compositions

Lymphokine

A61K 3819

Patent

active

056501471

ABSTRACT:
The present invention relates to the identification of promoters of myelopoietic blood cell production. In particular, an agent has been discovered that enhances myelopoietic colony stimulating factor activity. The agent comprises cytokines that are also capable of binding to heparin, and inducing localized inflammation characterized by polymorphonuclear cell infiltration when administered subcutaneously. Particular agents comprise the inflammatory cytokines MIP-1 and MIP-2. Diagnostic and therapeutic utilities are proposed, and pharmaceutical compositions are likewise set forth.

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