Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Reexamination Certificate
2005-06-21
2005-06-21
Leary, Louise N. (Department: 1654)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
C435S007100, C435S007200, C435S004000
Reexamination Certificate
active
06908744
ABSTRACT:
The disruption of the murine ROR2 gene leads to profound skeletal abnormalities, with essentially all endochondrally derived bones foreshortened and/or misshapen, albeit to differing degrees. ROR2 is selectively expressed in the chondrocytes of all developing cartilage anlagen, where it plays a critical role during initial growth and patterning, as well as subsequently in the proliferating chondrocytes of mature growth plates, where it is required for normal expansion. As ROR2 appears to play a critical role in cartilage formation and it may be useful in developing therapeutic strategies to treat diseases of cartilage such as osteoarthritis.
REFERENCES:
patent: 5843749 (1998-12-01), Maisonpierre et al.
patent: 5846770 (1998-12-01), LaVallie et al.
patent: 6586251 (2003-07-01), Economides et al.
patent: 6596541 (2003-07-01), Murphy et al.
Oldridge, M., et al., 2000, “Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B”, Nat Gen 24:275-278.
Saldanha, J., et al., 1998, “Indentification of a frizzled-like cysteine rich domain in the extracellular region of developmental receptor tyrosine kinases”, Prot Sci 7:1632-1635.
Takeuchi, S., et al, 2000, “Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation”, Genes to Cells 5:71-78.
DeChiara, T.M., 2000, “Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development”, Nat Gen 24:271-274.
DeChiara Thomas M.
Kimble Carrie A.
Yancopoulos George D.
Gregg, Esq. Valeta
Leary Louise N.
Regeneron Pharmaceuticals Inc.
LandOfFree
Methods of stimulating cartilage formation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of stimulating cartilage formation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of stimulating cartilage formation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3468496