Methods of stabilizing thimerosal in presence of polyvinylpyrrol

Details Methods of stabilizing thimerosal in presence of polyvinylpyrrol Methods of stabilizing thimerosal in presence of polyvinylpyrrol

1983-06-22

1984-07-17

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Lymphokine

424291, A61K 3179, A61K 31305, A01N 5506

Patent

active

044605730

ABSTRACT:
A method of preparing solutions containing thimerosal and polyvinylpyrrolidone which results in improved stability of thimerosal is disclosed. The method involves applying a certain amount of heat to the polyvinylpyrrolidone while it is in aqueous solution and prior to its combination with thimerosal. The required thermal input to the polyvinylpyrrolidone solution is a function of four variables: solution temperature, heating time, external pressure and polyvinylpyrrolidone concentration. Advantageously this method may be employed in the manufacture of contact lens solutions.

REFERENCES:
patent: 3755561 (1973-08-01), Rankin
patent: 3888782 (1975-06-01), Boghosian et al.
patent: 4029817 (1977-06-01), Blanco et al.
patent: 4120949 (1978-10-01), Bapatla et al.

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