Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing
Patent
1997-01-06
2000-10-24
Zitomer, Stephanie
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
435 691, 435325, 435366, A01K 3100, C12P 2100
Patent
active
061367796
ABSTRACT:
The present invention provides a method of transcriptionally modulating the expression of a gene-of-interest. The method comprises contacting a cell which is capable of expressing the gene with an amount of a molecule effective to transcriptionally modulate expression of the gene and thereby affect the level of the protein encoded by the gene which is expressed by the cell. Molecules useful in the practice of the invention are characterized as follows (a) do not naturally occur in the cell, (b) bind to DNA or RNA or bind to a protein through a domain of such protein which is not a ligand binding domain of a receptor which naturally occurs in the cell. Additionally, this invention provides a method for determining whether a molecule known to be a modulator of protein biosynthesis is capable of transcriptionally modulating expression of a gene-of-interest.
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Foulkes J. Gordon
Leichtfried Franz
Pieler Christian
Stephenson John R.
OSI Pharmaceuticals, Inc.
White John P.
Zitomer Stephanie
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