Methods of sensing with fluorescent conjugates of metal-chelatin

Details Methods of sensing with fluorescent conjugates of metal-chelatin Methods of sensing with fluorescent conjugates of metal-chelatin

1995-02-06

1997-07-15

Snay, Jeffrey

Chemistry: analytical and immunological testing

Metal or metal containing

Present in biological fluids

436 79, 436 80, 436 81, 436 82, 436 83, 436 84, 436172, G01N 3320

Patent

active

056482701

ABSTRACT:
The present invention describes the use of a family of fluorescent indicators for metal cations. The indicators are fluorophore conjugates of pyridyl-based metal ion chelators. The indicators are very sensitive detection as quantification reagents for a variety of metals, in a variety of oxidation states, even in the presence of high concentrations of Ca.sup.2+, Na.sup.+, or K.sup.+ or other ions, such as is found in seawater, making them highly useful for assaying physiological samples, biological samples, or environmental samples.

REFERENCES:
patent: 4603209 (1986-07-01), Tsien et al.
patent: 4774339 (1988-09-01), Haugland et al.
patent: 4849362 (1989-07-01), DeMarinis et al.
patent: 4945171 (1990-07-01), Haugland et al.
patent: 5049673 (1991-09-01), Tsien et al.
patent: 5134232 (1992-07-01), Tsien et al.
patent: 5135717 (1992-08-01), Renzoni et al.
patent: 5227487 (1993-07-01), Haugland et al.
patent: 5268486 (1993-12-01), Waggoner et al.
patent: 5274113 (1993-12-01), Kang et al.
Martell et al., Critical Stability Constants, vol. 1, Plenum Press, New York (1974).
Guilbault, Practical Fluorescence, 2nd Edition, Marcel Dekker, Publishers (1990).
Haugland, Molecular Probes Handbook of Fluorescent Probes and Research Chemicals (1992).
Bissel et al., Chem. Soc. Rev. 187 (1992).
Allen et al., Org. Synth. 2, 15 (1943).
Brinkley, Bioconj. Chem., 3, 2 (1992).

Affiliated with

Also associated with

Rating

Methods of sensing with fluorescent conjugates of metal-chelatin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of sensing with fluorescent conjugates of metal-chelatin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of sensing with fluorescent conjugates of metal-chelatin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1491906