Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-07-26
2011-07-26
Li, Ruixiang (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S350000
Reexamination Certificate
active
07985559
ABSTRACT:
The present application relates to methods of selecting EGFr binding agents. In certain embodiments, such EGFr binding agents bind to at least a portion of a panitumumab epitope on an EGFr. In certain embodiments, such EGFr binding agents do not bind to a panitumumab epitope on an EGFr.
REFERENCES:
patent: WO 98/50433 (1998-11-01), None
Amado et al., “Wild-typeKRASis required for panitumumab efficacy in patients with metastatic colorectal cancer,”J. Clin. Oncol, 26:1626-1634 (2008).
Friedman et al., “Synergistic down-regulation of receptor tyrosine kinases by combinations of mAbs: Implications for cancer immunotherapy,”PNAS, 102:1915-1920 (2005).
Imai et al., “Comparing antibody and small-molecule therapies for cancer,”Nature Reviews Cancer, 6:714-727 (2006).
Johns et al., “Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor,”J. Biol. Chem., 279: 30375-30384 (2004).
Li et al., “Structural basis for inhibition of the epidermal growth factor receptor by cetuximab,”Cancer Cell, 7:301-311 (2005).
Ward et al., “The insulin and EGF receptor structures: new insights into ligand-induced receptor activation,”TRENDS in Biochemical Sciences, 32: 129-137 (2007).
PCT Notification of Transmittal of the International Search Report and the Written Opinion of the International Searching Authority, or the Declaration, for International Application No. PCT/US2008/011882, dated Mar. 19, 2009.
Elliott Gary S.
Freeman Daniel J.
Jung Kenneth H.
Radinsky Robert
Sun Jilin
Amgen Inc.
Bernstein Scott N.
Li Ruixiang
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