Methods of screening test compounds using GADD34L, an...

Details Methods of screening test compounds using GADD34L, an... Methods of screening test compounds using GADD34L, an...

2006-08-29

2006-08-29

Gitomer, Ralph (Department: 1655)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

C435S375000

Reexamination Certificate

active

07097996

ABSTRACT:
The invention is directed to methods and reagents for identifying test substances useful for the prevention or treatment of diseases involving an oxidative stress. The methods involve screening assays, including high throughput screening techniques, in which the test substances are tested for their ability to promote resistance to oxidative stress by inhibiting the activity of GADD34L, and thereby inhibiting the dephosphorylation of eIF2α, while not causing stress.

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