Methods of screening nucleic acids using mass spectrometry

Details Methods of screening nucleic acids using mass spectrometry Methods of screening nucleic acids using mass spectrometry

1997-03-04

2000-04-18

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435 912, 536 231, 536 241, 536 2433, C12Q 168, C12P 1934, C07H 2102, C07H 2104

Patent

active

060513780

ABSTRACT:
This invention relates to methods for screening nucleic acids for mutations by analyzing nonrandomly fragmented nucleic acids using mass spectrometric techniques and to procedures for improving mass resolution and mass accuracy of these methods of detecting

REFERENCES:
patent: 4775619 (1988-10-01), Urdea
patent: 4935357 (1990-06-01), Szybalski
patent: 5003059 (1991-03-01), Brennan
patent: 5064754 (1991-11-01), Mills
patent: 5075217 (1991-12-01), Weber
patent: 5288644 (1994-02-01), Beavis et al.
patent: 5364759 (1994-11-01), Caskey et al.
patent: 5369004 (1994-11-01), Polymeropoulos et al.
patent: 5378602 (1995-01-01), Polymeropoulos et al.
patent: 5464985 (1995-11-01), Cornish et al.
patent: 5468610 (1995-11-01), Polymeropoulos et al.
patent: 5503980 (1996-04-01), Cantor
patent: 5508169 (1996-04-01), Deugau et al.
patent: 5547835 (1996-08-01), Koster
patent: 5580733 (1996-12-01), Levis et al.
patent: 5582979 (1996-12-01), Weber
patent: 5599666 (1997-02-01), Schumam et al.
patent: 5605798 (1997-02-01), Koster
patent: 5622824 (1997-04-01), Koster
patent: 5625184 (1997-04-01), Vestal et al.
patent: 5627369 (1997-05-01), Vestal et al.
patent: 5691141 (1997-11-01), Koster
patent: 5700642 (1997-12-01), Monforte et al.
patent: 5762876 (1998-06-01), Lincoln et al.
patent: 5885775 (1999-03-01), Haff et al.
patent: 5888819 (1999-03-01), Goelet et al.
Bukhard Herpich and Gerd-Joachim Krauss, "HPLC of Nucleic Acid Components with Volatile Mobile Phases I. Fast Nucleotide Separations using Ammonium Catrbonate and Ammonium Bicarbonate Gradients." Journal of High Resolutin Chromatography, vol. 15, p. 41, Jan. 1992.
Arnott et al., "Construction and performance of a laser desorption/ionization TOF mass spectrometer system: applications to problems in peptide, protein, and DNA structural analysis," The 40th ASMS Conference on Mass Spectrometry and Allied Topics, May 31-Jun. 5, Washington, D.C., pp. 328-329, 1992.
Bevan et al., "The analysis of oligonucleotides and their phosphoramidate analogues by LSIMS mass spectrometry," The 39th ASMS Conference on Mass Spectrometry and Allied Topics, pp. 983-984, 1989.
Edmonds et al., "Electrospray ionization mass spectrometry and tandem mass spectrometry of small oligonucleotides," 37th ASMS Conference on Mass Spectrometry and Allied Topics, May 21-26, Miami Beach, FL, pp. 844-845, 1989.
Jacobson et al., "Applications of mass spectrometry to DNA sequencing,", GATA, 8(8):223-229, 1991.
Karas and Bahr, "Matrix-assisted laser desorption ionization mass spectrometry," Mass Spectrometry Reviews, 10:335-357, 1991.
Limbach et al., "Characterization of oligonucleotides and nucleic acids by mass spectrometry," Current Opinion Biotechnology, 6:96-102, 1995.
McNeal et al., "A new method for the analysis of fully protected oligonucleotides by .sup.252 Cf-plasma desorption mass spectrometry. 3. Positive ions," J. Am. Chem. Soc., 104:981-984, 1982.
Mizusawa et al., "Improvement of the dideoxy chain termination method of DNA sequencing by use of deoxy-7-deazaguanosine triphosphate in place of dGTP," Nucl. Acids Res., 14(3):1319-1325, 1986.
Mock et al., "Sample immobilization protocols for matrix assisted laser desorption mass spectrometry," The 40th ASMS Conference on Mass Spectrometry and Allied Topics, pp. 1921-1922, 1992.
Musser and Kelley, "Sensitivity enhancement for static and continuous flow FAB/MS analysis of nucleotides by quaternary amine surfactants," The 39th ASMS Conference on Mass Spectrometry and Allied Topics, pp. 374-375, 1989.
Nordhoff et al., "Matrix-assisted laser desorption/ionization mass spectrometry of nucleic acids with wavelengths in the ultraviolet and infrared," Rapid Comm. Mass Spectrometry, 6:771-776, 1992.
Overberg et al., "Laser desorption mass spectrometry, Part II performance and applications of matrix-assisted laser desorption/ionization of large biomolecules," Anal. Chem., 181-197, 1992.
Parr et al., "Matrix-assisted laser desorption/ionization mass spectrometry of synthetic oligodeoxyribonucleotides," Rapid Comm. Mass Spectrometry, 6:369-372, 1992.
Spengler et al., "Molecular weight determination of underivatized oligodeoxyribonucleotides by positive-ion matrix-assisted ultraviolet laser-desorption mass spectrometry," Rapid Comm. Mass Spectrometry, 4(4):99-102, 1990.
Stahl et al., "Solid phase DNA sequencing using the biotin-avidin system," Nucl. Acids Res., 16(7):3025-3039, 1988.
Stults and Marsters, "Characterization of oligodeoxynucleotide conjugates by electrospray ionization mass spectrometry," Proceedings of the 39th ASMS Conference on Mass Spectrometry and Allied Topics, May 19-24, Nashville, TN, pp. 1161-1162, 1991.
Stults and Marsters, "Improved electrospray ionization of synthetic oligodeoxynucleotides," Rapid Comm. Mass Spectrometry, 5:359-363, 1991.
Tong and Smith, "Solid-phase method for the purification of DNA sequencing reactions," Anal. Chem., 64:2672-2677, 1992.
Trainor, "DNA sequencing, automation, and the human genome," Anal. Chem., 62:418-426, 1990.
PCT Search Report dated Jul. 23, 1997 International Application No. PCT/US 97/03499.
International Search Report dated Jan. 20, 1998(PCT/US 97/17101) (GETR:018P).
Sedlak, "GeneTrace Systems Bets its Future in Genomics on TOF Mass Spectroscopy," Genetic Engineering News, 16(21):, 1996. (website: http://www.genetrace.com).
Tang et al., "Detection of 500-Nucleotide DNA by Laser Desorption Mass Spectrometry," Rapid Commun. in Mass Spectrometry, 8(9):727-730, 1994.
Abrams, et al,. "Comprehensive Detection of Single Base Changes in Human Genomic DNA Using Denaturing Gradient Gel Electrophoresis and a GC Clamp," Genomics, 7:463-475, 1990.
Bai, Jian, et al., "Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry of Restriction Enzyme-Digested Plasmid DNA Using an Active Nafion Substrate," Rapid Commun. in Mass Spectrometry, 8:687-691, 1994.
Bai, Jian, et al., "Procedures for Detection of DNA by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Using a Modified Nafion Film Substrate," Rapid Commun. in Mass Spectrometry, 9:1172-1176, 1995.
Benner and Jaklevic, "DNA Base-Pair Substitutions Detected in Double-Stranded DNA With Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry," Eur. Mass Spectrum., 479-485, 1995.
Benner, Horn, Katz, Jaklevic, "Identification of Denatured Double-stranded DNA by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry," Rapid Commun. in Mass Spectrom., 9:537-540, 1995.
Bergh, et al., "Complete Sequencing of the p53 Gene Provides Prognostic Information in Breast Cancer Patients, Particularly in Relation to Adjuvant Systemic Therapy and Radiotherapy," Nature Medicine, 1:1029-1034, 1995.
Chang, et al., "Detection of .increment.F508 Mutation of the Cystic Fibrosis Gene by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry," Rapid Commun. in Mass Spectometry, 9:772-774, 1995.
Fang, et al., "Simultaneous Analysis of Mutant and Normal Alleles for Multiple Cystic Fibrosis Mutations by the Ligase Chain Reaction," Human Mutation, 6:144-151, 1995.
Fenn, et al., "Electrospray Ionization for Mass Spectrometry Large Biomolecules," Science, 246:64-71, 1989.
Hegner, Wagner, Semenza, "Ultralarge Atomically Flat Template-Stripped Au Surfaces for Scanning Probe Microscopy," Surface Science, 291:39-46, 1993.
Jurinke, Christian, et al., "Analysis of Ligase Chain Reaction Products Via Matrix-Assisted Laser Desorption/Ionization Time-of-Flight-Mass Spectrometry," Analytical Biochemistry, 237:174-181, 1996.
Kirpekar, Nordhoff, Kristiansen, Roepstorff, Lezius, Hahner, Karas, Hillenkamp, "Matrix Assisted Laser Desorption/Ionization Mass Spectrometry of Enzymatically Synthesized RNA Up to 150 kDa," Nucleic Acids Research, 22(19):3866-3870, 1994.
Kuimelis and McLaughlin, "Cleavage Properties of an Oligonucleotide Containing a Bridged Internucleotide 5'-phosphorothioate RNA Linkage," Nucleic Acids Research, 23:4753-4760, 1995.
Lee, et al., Comparison on Short Tandem Repeat (STR) Detection Using Silver, Fluorescence and Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrophotometry (

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