Methods of screening for ulcerative colitis and Crohn's disease

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 243, 435 6, C07H 2102, C07H 2104, C12Q 168

Patent

active

060083352

ABSTRACT:
A novel association between IBD and a polymorphism at amino acid residue 241 of ICAM-1 has been discovered. In accordance with the present invention there is provided methods of screening for IBD, methods for treating IBD, antibodies specifically reactive with ICAM-1 encoded by R241 allele and kits which exploit the inventive methods.

REFERENCES:
patent: 3654090 (1972-04-01), Schuurs
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 4016043 (1977-04-01), Schuurs et al.
patent: 4698195 (1987-10-01), Okumura et al.
patent: 4699880 (1987-10-01), Goldstein
patent: 4704692 (1987-11-01), Ladner
patent: 4800159 (1989-01-01), Mullis et al.
patent: 4935234 (1990-06-01), Todd et al.
patent: 5002873 (1991-03-01), St. John et al.
patent: 5091302 (1992-02-01), Newman et al.
patent: 5114842 (1992-05-01), Plow et al.
patent: 5137806 (1992-08-01), Lemaistre et al.
patent: 5147637 (1992-09-01), Wright et al.
patent: 5219997 (1993-06-01), Schlossman et al.
patent: 5227369 (1993-07-01), Rosen et al.
patent: 5234810 (1993-08-01), Kehrli, Jr. et al.
patent: 5235049 (1993-08-01), McClelland et al.
patent: 5264554 (1993-11-01), Newman
patent: 5272263 (1993-12-01), Hession et al.
patent: 5512439 (1996-04-01), Hornes et al.
patent: 5612216 (1997-03-01), Springer et al.
patent: 5681699 (1997-10-01), Rotter et al.
Vora et al., Genomics 21: 473-477 (Jun. 1994).
Voraberger et al., Journal of Immunology 147(8):2777-2786 (1991).
Staunton et al., Cell 52:925-933 (1988).
Ausubel, F. M. et al., eds., "Current Protocols in Molecular Biology," Wiley Intersciences, New York, (1987, 1989).
Ballanynte, C., et al., "Short Communication, Assignment of the Gene for Intercellular Adhesion Molecule-1 (Icam-1) to Proximal Mouse Chromosome 9," Genomics--9:547-550 (1991).
Benoit, R., et al., "Presence of somatostatin-28-(1-12) in hypothalamus and pancrease," Proc. Natl. Acad. Sci. USA--79:917-921 (1982).
Brambs et al., "Inflammatory Bowel Disease: Radiographical Diagnostics." (Reprints available at the Department of Radiography, Albert Ludwigs University Hospital, Freiburg, Federal Republic of Germany), pp. 3-62 (Undated).
Burks, C., et al., "GenBank," Nucleic Acids Res. (Suppl.)--20:2065-2069 (1992).
Cardullo, R.A., et al., "Detection of nucleic acid hybridization by nonradiative fluoresence resonance energy transfer," Proc. Natl. Acad. Sci. USA--85:8790-94 (1988).
Diamond, M.S., et al., "Binding of the Integrin Mac-1 (CD11b/CD18) to the Third Immunoglobulin-like Domain of ICAM-1 (CD54) and its Regulation by Glycosylation," Cell--65(6):961-971 (1991).
Fawcett, J., et al., "Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukycytes," Nature--360:481-84 (1992).
Hogg, N. and Landis, R., "Adhesion molecules in cell interactions," Curr. Opin. Immunol.--5:383-390 (1993).
Kita, Y., et al., "Sequence and expression of rat ICAM-1," Biochim. Biophys. Acta--1131:108-111 (1992).
Kuntz, H.D., et al., "Inflammatory Bowel Disease: Endoscopic Diagnostics." (Reprints available at the Department of Gastroenterology and Hepatology "Bergmannsheil" Hospital, University of Bochum, Federal Republic of Germany), pp. 3-38 (Undated).
Landegren, U., et al., "A Ligase-Mediated Gene Detection Technique," Science--241:1077-80 (1988).
Lasky, L., "Selectins: Interpreters of Cell-Specific Carbohydrate Information During Inflammation," Science--258:964-969 (1992).
Lemna, W.K., et al., "Mutation Analysis for Heterozygote Detection and the Prenatal Diagnosis of Cystic Fibrosis," N. Eng. J. Med.--322:291-296 (1990).
Lipsky, P., "Structure, Function and Regulation of Molecules Involved in Leukocyte Adhesion," New York: Springer-Verlag (1993) (Book-not being sent).
Lorenz-Meyer, H., "Inflammatory Bowel Disease Laboratory Diagnostics." (Reprints available from the City Hospital, Friedrichshafen, Federal Republic of Germany), pp. 3-29 (Undated).
Maniatis, T. et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, pp. (1982).
McEver, R. "Leukocyte--endothelial cell interactions," Curr. Opin. Cell. Biol.--4:840-849 (1992).
Nakamura, S., et al., "In situ expression of the cell adhesion molecules in inflammatory bowel disease: Evidence of immunologic activation of vascular endothelial cells," Lab Invest.--69(1):77-85 (1993).
Saxon, E.Z., et al., "A Distinct Subset of Antineutrophil Cytoplasmic Antibodies is Associated with Inflammatory Bowel Disease," J. Allergy Clin. Immunol.--86(2):202-210 (1990).
Schelomerich, J., "Inflammatory Bowel Diseases: Early Symptoms and Differential Diagnosis of Chronic Inflammatory Bowel Diseases," (Reprints available from the University of Freiburg, Department of Internal Medicine, Hugstetter Strasse 55, D-7800 Freiburg, W. Germany), pp. 2-20.
Shanahan, F., et al., "Inflammatory Bowel Disease," Textbook of Internal Medicine--81:489-502; (W.N. Kelley et al. (editor), 2.sup.nd edition, J.B. Lippincott Company, Philadelphia, PA (1992).
Smith, C., "Transendothelial Migration," Harlan, J. and Liu, D., eds., W.H. Freeman & Co., New York, pp. 83-115 (1992).
Smith, C., et al., "Adherence of Neutrophils to Canine Cardiac Myocytes In Vitro Is Dependent on Intercellular Adhesion Molecule-1," J. Clin. Invest.--88:1216-1223 (1991).
Smith, C.W., et al., "Recognition of an Endothelial Determinant for CD18-dependent Human Neutrophil Adherence and Transendothelial Migration," J. Clin. Invest.--82:1746-1756 (1988).
Springer, T.A., et al., "Leukocyte Adhesion Molecules Structure Function and Regulation," New York, Springer-Velag (1990) (Book--Table of Contents).
Springer, T.A., et al., "Adhesion receptors of the immune system," Nature--346:425-433 (1990).
Staunton D.E., et al., "Primary Structure of ICAM-1 Demonstrates Interaction Between Members of the Immunoglobulin and Integrin Supergene Families," Cell--52:925-933 (1988).
Stites, D. P., et al., Chapter 22 of the 4.sup.th edition of Basic and Clinical Immunology, Lange Medical Publications, Los Altos, California (1982).
Tomassini, J.E., et al., "cDNA Cloning Reveals That The Major Group Rhinovirus Receptor on HeLa Cells is Intercellular Adhesion Molecule 1, " Proc. Natl. Acad. Sci. USA--86:4907-4911 (1989).
Voraberger, G., et al., "Cloning of the Human Gene For Intercellular Adhesion Molecule 1 and Analysis of Its 5'Regulatory Region," The Journal of Immunology--147(8):2777-2786 (1991).
Weber, J. and May, P., "Abundant Class of Human DNA Polymorphisms Which Can Be Typed Using the Polymerase Chain Reaction," Am. J. Hum. Genet.--44:388-396 (1989).
Yang, H. et al., "Association of intercellular adhesion-molecule-1 (ICAM-1) gene with subsets of inflammatory bowel disease (BID) stratified by anti neutrophil cytoplasmic antibodies (ANCAs)," Clinical Research--42(1):76A (1994).
Yang, H., et al., "Genetic Heterogeneity Within UC and Crohn's Defined by Antineutrophil Cytoplasmic Antibodies (ANCAs) and Intercellular Adhesion Molecule-1 (ICAM-1) Polymorphisms," Gastroenterology 106(4) Part 2 (A794-AGA Abstracts).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods of screening for ulcerative colitis and Crohn's disease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of screening for ulcerative colitis and Crohn's disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of screening for ulcerative colitis and Crohn's disease will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2383220

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.