Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-10-07
1997-11-25
Saunders, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 724, 435 725, 435 732, 435 79, 435 795, 435961, 435965, 435975, 436506, 436508, G01N 33564
Patent
active
056911513
ABSTRACT:
The present invention provides novel methods of screening for ulcerative colitis and Crohn's disease which include the detection of two disparate autoantibodies: pANCA and VH3-15 autoantibody. The present invention also provides kits for screening ulcerative colitis and Crohn's disease.
REFERENCES:
patent: 5292667 (1994-03-01), Podolsky et al.
Berberian, L.S. et al., Journal of Immunology, "Expression of a Novel Autoantibody Defined by the V.sub.H 3-15 Gene in Inflammatory Bowel Disease and Campylobacter jejuni Enterocolitis", 153:(8):3756-3763 (1994).
Pallone, F. et al., J. Clin. Lab. Immunol., "Raised Serum Levels of IgM-Rheumatoid Factor And Anti-F(ab)2 Autoantibodies In Patients With Active Inflammatory Bowel Disease", 19(4):175-180 (1986).
Peter, H.H. et al., Journal of Interferon Research, "Novel Autoantibodies In Human Diseases", 14(4):153-155 (1994).
Adderson, E.E., et al., "Development of the Human Antibody Repertoire." Pediatr. Res., 32(3): 257-263 (1992).
Cleveland, D. W., et al., "Peptide Mapping by Limited Proteolysis in Sodium Dodecyl Sulfate and Analysis by Gel Electrophoresis." J. Biol. Chem. 252(3): 1102-1106 (1977).
Lesavre, P., et al., "Atypical Autoantigen Targets of Perinuclear Antineutrophil Cytoplasm Antibodies (P-ANCA): Specificity and Clinical Associations." J. Autoimmunity 6: 185-195 (1993).
Perdigoto, R., et al., "Frequency and significance of chronic ulcerative colitis in severe corticosteroid-treated autoimmune hepatitis." J. Hepatology 14: 325-331 (1992).
Warny, M., et al., "Anti-neutrophil antibodies in chronic hepatitis and the effect of .alpha.-interferon therapy." J. Hepatology 17: 294-300 (1993).
Adderson, E.E., et al., "Restricted Ig H Chain V Gene Usage in the Human Antibody Response to Haemophilus influenzae Type b Capsular Polysaccharide." J. Immunol., 147: 1667-1674 (1991).
Adderson, E. E., et al., "The Human VH3b Gene Subfamily Is Highly Polymorphic." J. Immunol., 151(2): 800-809 (1993).
Adderson, E. E., et al., "Restricted Immunoglobulin VH Usage and VDJ Combinations in the Human Response to Haemophilus influenzae Type b Capsular Polysaccharide. Nucleotide Sequences of Monospecific Anti-Haemophilus Antibodies and Polyspecific Antibodies Cross-reacting with Self Antigens." J. Clin. Invest., 91(6): 2734-2743 (1993).
Andris, J. S., et al., "Molecular Characterization of Human Antibodies of Bacterial Antigens: Utilization of the Less Frequently Expressed V.sub.H 2 and V.sub.H 6 Heavy Chain Variable Region Gene Families." Mol. Immunol., 30: 1601-1616. (1993).
Axelrod, O., et al., "Idiotypic Cross-Reactivity of Immunoglobulins Expressed in Waldenstrom's Macroglobulinemia, Chronic Lymphocytic Leukemia, and Mantle Zone Lymphocytes of Secondary B-cell Follicles." Blood, 77: 1484-1490 (1991).
Berberian, L., et al., "Immunoglobulin V.sub.H 3 Gene Products: Natural Ligands for HIV gp120." Science, 261: 1588-1591 (1993).
Blaser, M. J., et al., "Studies of Campylobacter jejuni in Patients With Inflammatory Bowel Disease." Gastroenterology, 86: 33-38 (1984).
Blaser, M. J., et al., "Camphyobacter jejuni Outer Membrane Proteins Are Antigenic for Humans." Infect. Immun., 43(3): 986-993 (1984).
Blaser, M. J., et al., "Human Serum Antibody Response to Campylobacter jejuni Infection as Measured in an Enzyme-Linked Immunosorbent Assay." Infec. Immun., 44(2): 292-298 (1984).
Blaser, M. J., et al., "Antigenicity of Campylobacter jejuni Flagella." Infec. Immun., 53(1): 47-52 (1986).
Braun, J., et al., "Restricted Use of Fetal VH3 Immunoglobulin Genes by Unselected B Cells in the Adult. Predominance of 56p 1-like VH Genes in Commom Variable Immunodeficiency." J. Clin. Invest., 89: 1395-1402 (1992).
Chamberlain, C. E., et al., "Campylobacter (Halicobacter) pylori: Is Peptic Disease a Bacterial Infection?" Arch. Intern Med., 150: 951-955 (1990).
Cook, G. P., et al., "A map of the human immunoglobulin V.sub.H locus completed by analysis of the telomeric region of chromosome 14q." Nature Genet., 7(2): 162-168 (1994).
Das, K.M., et al., "The Production and Characterization of Monoclonal Antibodies to A Human Colonic Antigen Associated with Ulcerative Colitis: Cellular Localization of the Antigen by Using the Monoclonal Antibody." J. Immunology, 139: 77-84 (1987).
Das, K. M.,et al., "A Shared and Unique Epitope(s) on Human Colon, Skin, and Biliary Epithelium Detected by a Monoclonal Antibody." Gastroenterology, 98: 464-469 (1990).
Deane, M., et al., "The Genetic Basis of Human V.sub.H 4 Gene Family-Associated Cross-Reactive Idiotype Expression in CD5 + and CD5- Cord Blood B-Lympohocyte Clones." Scand. J. Immunol., 38: 348-358 (1993).
Duerr, R. H., et al., "Anti-Neutrophil Crytoplasmic Antibodies in Ulcerative Colitis. Comparison With Other Colitides/Diarrheal Illnesses." Gastroenterology 100: 1590-1596 (1991).
Eggena, M., et al., "Characterization of Ulcerative Colitis Specific pANCA Using Phage Display Technology." J. Amer. Soc. Exper. Biol., 8(5): A1010 (1994).
Elsaghier, A., et al., "Antibodies to Mycobacterium paratuberculosis-specific protein antigens in Crohn's disease." Clin. Exp. Immunol., 90: 503-588 (1992).
Ermel, R. W., et al., "Preferential Utilization of a Novel Vlambda3 Gene in Monoclonal Rheumatoid Factors Derived From the Synovial Cells of Rheumatoid Arthritis Patients." Arthritis Rheum., 37(6): 860-868 (1994).
Graham, D. Y., "Campylobacter pylori and Peptic Ulcer Disease." Gastroenterology, 96: 615-625 (1989).
Griffiths, A. D., et al., "Human anti-self antibodies wwith high specificity from phage display libraries." EMBO J., 12: 725-734 (1993).
Huang, C., et al.,"A Majority of Ig H Chain cDNA of Normal Human Adult Blood Lymphocytes Resembles cDNA for Fetal Ig and Natural Autoantibodies." J. Immunol., 151: 5290-5300 (1993).
Jefferies, L. C., et al., "Idiotypic Heterogeneity of Vkappalll Autoantibodies to Red Blood Cell Antigens." Clin. Immunol. Immunopathol., 65(2): 119-128 (1992).
Johnson, R. J., et al., "Persistent Campylobacter jejuni Infection in an Immunocompromised Patient." Ann. Intern. Med., 100: 832-834 (1984).
Jonusys, A. M., et al., "IgM Natural Autoantibodies Against Bromelain-Treated Mouse Red Blood Cells Recognize Carbonic Anhydrase." Autoimmunity, 9: 207-216 (1991).
Kearney, J. F., "Idiotypic Networks." Fundamental Immunology. 3 ed. Paul, W. New York: Raven Press; 1993; c. 1993: 887-902. (Paul, W.). ISBN: 0-7817-0022-1.
Kipps, T. J., et al., "Uniform High Frequency Expression of Autoantibody-Associated Crossreactive Idiotypes in the Primary B Cell Follicles of Human Fetal Spleen." J. Exp. Med., 171: 189-196 (1990).
Kipps, T. J., et al., "Autoantibodies in Chronic Lymphocytic Leukemia and Related Systemic Autoimmune Diseases." Blood, 81: 2475-2487 (1993).
Langman, R. E., et al., "The `complete` idiotype network is an absurd immune system." Immunol. Today, 7: 100-103 (1986).
Lindberg, E., et al., "Antibody (IgG, IgA, and IgM) to baker's yeast (Saccharomyces cerevisiae), yeast mannan, gliadin, ovalbumin, and betalactoglobulin in monozygotic twins with inflammatory bowel disease." Gut, 33: 909-913 (1992).
Lydyard, P. M., et al., "The Antibody Repertoire of Early Human B Cells. III. Expression of Cross-Reactive Idiotopes Characteristic of Certain Rheumatoid Factors and Identifying Vkappalll, V.sub.H I, and V.sub.H III Gene Family Products." Scand. J. Immunol., 32: 709-716 (1990).
Lynch, R. G., "Myeloma Proteins and Cells: Monoclonal Tools in the Analysis of Immunoregulatory Mechanisms." Hybridoma, 3: 60 (1984).
MacKenzie, L. E., et al., "Repertoire of CD5 + and CD5- cord blood B cells: specificity and expression of V.sub.H I and V.sub.H III associated idiotopes." Clin. Exp. Immunol., 88(1): 107-111 (1992).
Mageed, R. A., et al., "Selective Expression of V.sub.H IV Subfamily of Immunoglobulin Genes in Human CD5 + B Lymphocytes from Cord Blood." J. Exp. Med., 174: 109-113 (1991).
Matsuda, F., et al., "Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy-chain locus." Nature Genetics, 3: 88-94 (1993).
Modlin, R. L., et al., "Type 2 cytokines and negative immune regulation in human in
Braun Jonathan
Targan Stephan R.
Regents of University of California
Saunders David
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