Methods of screening for non-hormone compounds which effect modu

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 8, 435 6, 435 74, 435 29, 435 691, 435 697, G01N 33567, G01N 33573, C12Q 166, C12P 2106

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058742310

ABSTRACT:
Method for screening for a non-hormone agent potentially useful to treat a hormone disorder. The method involves contacting a potential agent with a system containing a cellular component and a translation factor. The component and factor interact with one another in an intact normal cell in a manner responsive to the hormone to cause a modulation of translation in the cell. The method involves determining whether the agent causes a modulation of translation by the component and the factor analogous to that which occurs in intact cells in response to the hormone.

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Kai

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