Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-09-30
2008-09-30
Saucier, Sandra (Department: 1651)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S015000, C435S184000, C435S193000
Reexamination Certificate
active
10342311
ABSTRACT:
The present invention discloses methods of screening for identification of compounds that inhibit novel targets in the enzymatic pathway of phospholipid synthesis that are related to glycolipid storage diseases, and use of the compounds for treating patients affected with glycolipid storage diseases, particularly Gaucher disease. Specifically, the compounds of the present invention are intended to inhibit the accumulation of phosphatidylcholine (PC), wherein PC accumulation is increased due to the activation of CTP:phosphocholine cytidylyltransferase (CCT) upon glucosylceramide (GlcCer) accumulation.
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Norman S. Radin et al., “Chemotherapy by Slowing Gl
Bodennec Jacques
Futerman Anthony H.
Pelled Dori
Hanley Susan
Saucier Sandra
Winston & Strawn LLP
Yeda Research and Development Co. Ltd.
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