Methods of screening for compounds with ability to alter apolipo

Details Methods of screening for compounds with ability to alter apolipo Methods of screening for compounds with ability to alter apolipo

1994-06-08

1998-02-24

Guzo, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 71, C12Q 168, G01N 3353

Patent

active

057210969

ABSTRACT:
Activation of the apolipoprotein AI (apoAI) gene in mammalian liver cells has been studied, as described herein, and shown to depend on synergistic interactions between nuclear proteins which bind to three distinct sites within a hepatocyte-specific transcriptional enhancer located between nucleotides -222 to -110 5' of the human apoAI gene (relative to the transcription start site). Two proteins, the apoAI regulatory protein-1 and the retinoic acid receptor RXR.alpha., have been shown to regulate expression of the apoAI gene.

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