Methods of screening for compounds which mimic galectin-1

Details Methods of screening for compounds which mimic galectin-1 Methods of screening for compounds which mimic galectin-1

1997-09-05

1999-09-07

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 18, 435375, C12Q 134, G01N 3353

Patent

active

059486287

ABSTRACT:
Methods for treating and modulating an inflammatory response using compositions containing a primarily monomeric or primarily dimeric form of galectin-1. The dimeric form stimulates apoptosis of activated neutrophils while the monomeric form inhibits apoptosis of activated neutrophils. Methods of screening for compounds which have galectin-1-like functions are also identified.

REFERENCES:
patent: 5587460 (1996-12-01), Nedwin et al.
Perillo, N.L., et al., Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes. J. Exp. Med. 185:(10)1851-1858, May 1997.
Timoshenko, A.V., et al., Viscum album agglutinin-induced aggregation of blood cells and the lectin effects on neutrophil function. Biomed. Pharmacol. 49:153-158, 1995.
Homburg et al., "Human Neutrophils Lose their Surface Fc.gamma.RII and Acquire Annexin V Binding Sites During Apoptosis In Vitro", Blood, vol. 85, No. 2, pp. 532-540, Jan. 15, 1995.
Perillo et al., "Apoptosis of T-Cells Mediated by Galectin-1", Nature, vol. 378, pp. 736-739, Dec. 14, 1995.
R.D. Cummings and M. Cho, "Characterization of Monomeric Forms of Galectin-1 Generated by Site-Directed Mutagenesis", Biochemistry, vol. 35, No. 40, pp. 13082-13088, Dec. 1996.

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