Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-04-19
2011-04-19
Swartz, Rodney P. (Department: 1645)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C536S024300, C536S024320, C435S004000, C435S007800, C435S032000, C424S009100, C424S009200, C424S184100, C424S191100, C424S265100, C424S268100
Reexamination Certificate
active
07928215
ABSTRACT:
The present inventors succeeded in isolating GWT1 (PfGWT1), which is one of the enzymes involved in GPI biosynthesis in the malaria parasiteP. falciparum. In addition, the inventors revealed that degenerate mutant DNAs, with a lower AT content than the DNA encoding the PfGWT1 protein, can complement the phenotype of GWT1-deficient yeast. Based on the findings, the present invention provides the GWT1 protein of malaria parasites and the use of the protein in methods of screening for antimalarial drugs. The present invention also provides degenerate mutant DNAs encoding proteins involved in GPI biosynthesis, and which have a lower AT content than the original DNAs. The present invention also provides methods of screening for antimalarial drugs which use the degenerate mutant DNAs.
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Hata Katsura
Horii Toshihiro
Nakamoto Kazutaka
Ogawa Kaoru
Sagane Koji
EISAI R&D Management Co., Ltd.
Kilpatrick Townsend & Stockton LLP
Swartz Rodney P.
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