Methods of screening for compounds that improve engraftment

Details Methods of screening for compounds that improve engraftment Methods of screening for compounds that improve engraftment

2005-10-17

2008-09-30

Strzelecka, Teresa (Department: 1637)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C435S091200, C435S370000, C514S012200

Reexamination Certificate

active

07429376

ABSTRACT:
The invention provides for methods of screening for compounds that increase the expression of P-selectin, SDF-1, and/or CXCR4 on facilitatory cells (FCs). The invention also provides for methods of screening for compounds that increase the level of p-predendritic cells (p-pre DC) without substantially decreasing the level of natural killer (NK) cells in a population of FCs. The invention further provides for methods of characterizing the facilitating capability of FCs by evaluating such cells for the amount of P-selectin, SDF-1, and/or CXCR4.

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