Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-03-14
1999-12-28
Myers, Carla J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 4, 435 72, 435 15, 435 912, 435 911, 435375, C12Q 168, C12P 1934
Patent
active
060079894
ABSTRACT:
Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to increase or decrease telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity and means are shown for slowing or reversing the loss of telomeric repeats in aging cells.
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Blackburn Elizabeth H.
Harley Calvin B.
Kim Nam Woo
McEachern Michael J.
Shay Jerry
Board of Regents , The University of Texas System
Geron Corporation
Myers Carla J.
The Regents of the University of California
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