Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-10-27
1997-02-18
Ziska, Suzanne E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
424 92, 435 721, 4351723, 800 2, 530350, C12N 1500, G01N 3353, G01N 33567, A61K 4900
Patent
active
056041020
ABSTRACT:
Processing of .beta.-amyloid precursor protein (.beta.APP) is monitored by detecting the secretion of a soluble amino-terminal fragment or .beta.APP (ATF-.beta.APP) resulting from cleavage of .beta.APP at the amino-terminus of .beta.-amyloid peptide. Secretion of ATF-.beta.APP in animal models may be monitored to identify inhibitors of .beta.-amyloid production. The ATF-.beta.APP may be detected using antibodies and other specific binding substances which recognize a carboxy terminal residue on the fragment. Animals expressing the Swedish mutation of .beta.APP are described which produce abundant amounts of ATF-.beta.APP.
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McConlogue Lisa C.
Schenk Dale B.
Seubert Peter A.
Sinha Sukanto
Zhao Jun
Athena Neurosciences, Inc.
Ziska Suzanne E.
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