Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1998-12-08
2000-09-05
Ulm, John
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 435 72, 436501, G01N 3353, G01N 33567
Patent
active
061141275
ABSTRACT:
HDPXU17 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods of screening for agonists and antagonists of the interaction between the HDPXU17 receptor and its ligands, dexoyadenosine triphosphate ("dATP"), deoxyadenosine monophosphate ("dAMP"), and uridine triphosphate ("UTP").
REFERENCES:
Communi, et al., "Cloning of a Human Purinergic 8Y Receptor Coupled to Phospholipase C and Adenylyl Cyclase," J. Biol. Chem., 272:31969-31973 (1997).
Human Genome Sciences Corporation (HGS) EST#2295303.
Ayyanathan, K., et al., "Cloning and Chromosomal Localization of the Human P2Y1 Purinoceptor"Biochemical and Biophysical Res. Commun. 218(3): 783-788 (1996).
Takeda, J., et al., "A molecular inventory of human pancreatic islets: sequence analysis of 1000 cDna clones"Human.Molecular.Genetics:2(11), 1793-1798 (1993).
GenBank Accession #AF030335.
GenBank Accession #Z49205.
GenBank Accession #T10449.
GenBank Accession #AA405284.
Bergsma Derk J.
Culp Jeffrey S.
Halsey Wendy S.
Sathe Ganesh M.
Wang Da-Yuan
Hecht Elizabeth J.
King William T.
Kinzig Charles M.
SmithKline Beecham Corporation
Ulm John
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