Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-07
1998-12-29
Cunningham, Thomas M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 721, 435 724, 435 78, 435 793, 435 792, 436 86, 436501, 530324, 530325, 530326, 530327, 530328, 530329, 530330, G01N 3353, C07K 510, C07K 706, C07K 1400
Patent
active
058539999
ABSTRACT:
Methods and compositions are provided for regulating surface membrane receptor responses by modulating interaction between MHC Class I antigen and the surface membrane receptor. Various techniques may be employed for enhancing or reducing the interaction between the MHC Class I antigen and surface membrane receptor (e.g., enhancing surface expression of the MHC Class I antigen or employing agents which affect interaction between MHC Class I antigen and surface receptors). The aggregative characteristics of oligopeptides which act as agents in affecting interaction between MHC Class I antigen and surface receptors may be employed in a screening assay for determining drugs which affect interaction between Class I antigen and surface receptors. Active peptide aggregative characteristics may also be employed in a method of administration of effectors of surface receptor response modulation.
REFERENCES:
patent: 5073540 (1991-12-01), Olsson
Due et al., "The major Histocompatibility Complex Class I Heavy Chain as a Structural Subunit of the Human Cell Membrane Insulin Receptor: Implications for the Range of Biological Functions of Histocompability Antigens", P.N.A.S. (USA) (1986), 83:6007-6011.
Fehlmann et al., "Molecular Association Between Major Histocompatibility Complex Class I Antigens and Insulin Receptors in Mouse Liver Membrances", P.N.A.S. (USA) (1985), 82:8634-8637.
Lafuse et al., "Interaction of the Mouse major Histocompatibility Complex, H-2, on Liver Adenylate Cyclase Activity and on Glucagon Binding to Liver Cell Membranes", Biochemistry (1980), 1:49-54.
Paul, Fundamental Immunology, 2d Edition (1989), 652-653.
Phillips et al., "Class I Histocompability Antigens and Insulin Receptors: Evidence for Interactions", P.N.A.S. (USA) (1986), 83:3474-3478.
Cotran et al., Robbins Pathological Basis of Disease, 4th Edition (1989), 994-1001.
Ruoslathti, E., et al., Synthetic Peptides in Biology and Medicine (1985), 191-197, Alitalo, et al., (editors), Elsevier Science Publishers B.V. (Biomedical Division), the Netherlands.
Schreiber et al., "Interaction Between Major Histocompability Complex Antigens and Epidermal Growth Factor Receptors on Human Cells", J. Cell Biol. (1984), 98:725-731.
Simonsen et al., "Possible Roles of Compound Membrane Receptors in the Immune System", Ann. Immunology (Inst. Pasteur) 134D (1983), 85-92.
Stagsted et al., "Correlation Between Insulin Receptor Occupancy and Tyrosine Kinase Activity at Low Insulin Concentrations and Effect of Major Histocompability Complex Class I-Derived Peptide", J. Pharm. and Exp. Therapeutics (1993), 267:997-1001.
Stagsted et al., "A Preformed, Ordered Structure of a 25-residue Peptide Derived From a major Histocompability Complex Class I Antigen is Required to Affect Insulin Receptor Function", J. Biological Chem. (1991), 266:12844-12847.
Verland et al., "Specific Molecular Interaction Between the Insulin Receptor and A D Product of MHC Class I", J. of Immun. (1989), 143:945-951.
Stagsted et al., "Regulation of Insulin Receptor Functions by a Peptide Derived from a Major Histocompability Complex Class I Antigen", Cell (1990), 62:297-307.
Stagsted et al., "Insulinomimetic Effect on Glucose Transport by Epidermal Growth Factor When Combined with a Major Histocompability Complex Class I-derived Peptide", J. of Biological Chem. (1993), 268: 1770-1774.
Stagsted et al., "Inhibition of Internalization of Glucose Transporters and IGF-II Receptors", J. of Biological Chem. (1993), 268:22809-22813.
Stagsted et al., "Amino Acid Residues Essential for Biological Activity of a Peptide Derived from a Major Histocompatibility Complex Class I Antigen", P.N.A.S. (1993), 90:7686-7690.
Goldstein Avram
Goodenow Robert S.
Olsson Lennart
Cunningham Thomas M.
Lubet Martha
The Regents of the University of California
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