Methods of screening for a tumor or tumor progression to the met

Details Methods of screening for a tumor or tumor progression to the met Methods of screening for a tumor or tumor progression to the met

1997-03-17

1999-08-31

Hannaher, Constantine

Radiant energy

Invisible radiant energy responsive electric signalling

Infrared responsive

25033908, A61B 600, G01N 2135

Patent

active

059456752

ABSTRACT:
Methods of screening for a tumor or tumor progression to the metastatic state are a provided. The screening methods are based on the characterization of DNA by principal components analysis of spectral data yielded by Fourier transform-infrared spectroscopy of DNA samples. The methods are applicable to a wide variety of DNA samples and cancer types.

REFERENCES:
patent: 5435309 (1995-07-01), Thomas et al.
patent: 5596992 (1997-01-01), Haaland et al.
Malins et al., "The Etiology and Prediction of Breast Cancer," Cancer 75(2): 503-517, Jan. 1995.
Malins et al., "Progression of human breast cancers to the metastatic state is linked to hydroxyl radical-induced DNA damage," Proc. Natl. Acad. Sci. USA 93: 2557-2563, Mar. 1996.
Malins et al., "Tumor progression to the metastatic state involves structural modifications in DNA markedly different from those associated with primary tumor formation," Proc. Natl. Acad. Sci. USA 93: 14047-14052, Nov. 1996.

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