Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-01-16
2007-01-16
Ulm, John (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C435S007200, C436S501000
Reexamination Certificate
active
10633438
ABSTRACT:
The methods of the present invention allow the screening of a test composition for non-receptor-specific GPCR desensitization inhibitory activity. The methods involve screening a test composition for an indication of GPCR desensitization inhibitory activity against two or more GPCRs that are different from each other. When there is an indication that a particular test composition has GPCR desensitization inhibitory activity with respect to each of the two or more GPCRs that are different from one another, then, according to the present invention, there is an indication that the test composition has non-receptor-specific GPCR desensitization inhibitory activity.
REFERENCES:
patent: 3654090 (1972-04-01), Schuurs et al.
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 4016043 (1977-04-01), Schuurs et al.
patent: 4341761 (1982-07-01), Ganfield et al.
patent: RE31006 (1982-08-01), Schuurs et al.
patent: 4342566 (1982-08-01), Theofilopoulos et al.
patent: 4399121 (1983-08-01), Albarella et al.
patent: 4427783 (1984-01-01), Newman et al.
patent: 4444887 (1984-04-01), Hoffmann
patent: 4451570 (1984-05-01), Royston et al.
patent: 4466917 (1984-08-01), Nussenzweig et al.
patent: 4472500 (1984-09-01), Milstein et al.
patent: 4491632 (1985-01-01), Wands et al.
patent: 4493890 (1985-01-01), Morris
patent: 4816397 (1989-03-01), Boss et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4981784 (1991-01-01), Evans et al.
patent: 5284746 (1994-02-01), Sledziewski et al.
patent: 5366889 (1994-11-01), MacDonald et al.
patent: 5468854 (1995-11-01), McCabe et al.
patent: 5482835 (1996-01-01), King et al.
patent: 5491084 (1996-02-01), Chalfie et al.
patent: 5532157 (1996-07-01), Fink
patent: 5576436 (1996-11-01), McCabe et al.
patent: 5625048 (1997-04-01), Tsien et al.
patent: 5777079 (1998-07-01), Tsien et al.
patent: 5804387 (1998-09-01), Cormack et al.
patent: 5891646 (1999-04-01), Barak et al.
patent: 5958713 (1999-09-01), Thastrup et al.
patent: 5989835 (1999-11-01), Dunlay et al.
patent: 6066476 (2000-05-01), Tsien et al.
patent: 6096705 (2000-08-01), Lefkowitz et al.
patent: 6107324 (2000-08-01), Behan et al.
patent: 6110693 (2000-08-01), Barak et al.
patent: 6140509 (2000-10-01), Behan et al.
patent: 6150393 (2000-11-01), Behan et al.
patent: 6528271 (2003-03-01), Bohn et al.
patent: 2002/0106739 (2002-08-01), Oakley et al.
patent: 2003/0013137 (2003-01-01), Barak et al.
patent: 2003/0049643 (2003-03-01), Barak et al.
patent: 2004/0029190 (2004-02-01), Barak et al.
patent: 88/03168 (1988-05-01), None
patent: 94/16684 (1994-08-01), None
patent: 98/12310 (1998-03-01), None
patent: 98/44350 (1998-10-01), None
patent: 99/66324 (1999-12-01), None
patent: 00/12704 (2000-03-01), None
patent: 01/58923 (2001-08-01), None
patent: 02/059267 (2002-08-01), None
Gurevich et al. Arrestin Interactions with G Protein-coupled Receptors. Jan. 13, 1995. J. Biol. Chem. 270(2):720-731.
Hodgson, J. Receptor Screening and the Search for New Pharmaceuticals. Sep. 10, 1992. BIO/TECHNOLOGY 10:973-977.
Walker, Julia K. L., et al.,Properties of Secretin Receptor Internalization Differ from Those of the β2-Adrenergic Receptor*, Journal of Biological Chemistry, vol. 274, No. 44, Oct. 29, 1999, pp. 31515-31523, The American Society for Biochemistry and Molecular Biology. Inc., U.S.A.
Oakley et al.,The Cellular Distribution of Fluorescently Labeled Arrestins Provides a Robust, Sensitive, and Universal Assay for Screening G Protein-Coupled Receptors, ASSAY and Drug Development Technologies, vol. 1, No. 1-1, 2002, pp. 21-30.
Angers, S., et al.,Detection of β2-Adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer(BRET),Proceedings of the National Academy of Sciences, vol. 97, No. 7, Mar. 28, 2000, pp. 3684-3689, Proc. Natl. Acad. Sci., USA.
Attramadal, H., et al., β2-Arrestin2, a Novel Member of the Arrestin/ β-Arrestin Gene Family, Journal of Biological Chemistry, vol. 257, No. 25, Sep. 5, 1992, pp. 17882-17890, The American Society for Biochemistry and Molecular Biology, Inc., USA.
Barak, et al.,Abstract #2484, Molecular Biology of the Cell, vol. 7, p. 427a Dec. 1996, 6thInternational Congress on Cell Biology & 36thAmerican Society for Cell Biology Annual Meeting, Dec. 7-11, 1996, San Francisco, CA.
Barak, L.S., et al.,Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus, Proceedings of the National Academy of Sciences, vol. 98, No. 1, Jan. 2, 2001, pp. 93-98, Proc. Natl. Acad. Sci., USA.
Barak, L.S., et al.,A highly Conserved Tyrosine Residue in G Protein-Coupled Receptors is Required for Agonist-mediated β2-Adrenergic Receptor Sequestration, Journal of Biological Chemistry, vol. 269, No. 4, Jan. 28, 1994, pp. 2790-2795, The American Society for Biochemistry and Molecular Biology, Inc., USA.
Barak, L.S., et al.,A β-Arrestin/Green Fluorescent Protein Biosensor for Detecting G Protein-coupled Receptor Activation, Journal of Biological Chemistry, vol. 272, No. 44, Oct. 31, 1997, pp. 27497-27500, The American Society for Biochemistry and Molecular Biology, Inc., USA.
Barak, L.S., et al.,The Conserved Seven-Transmembrane Sequence NP(X)22Y of the G-Protein-Coupled Receptor Superfamily Regulates Multiple Properties of the β2-Adrenergic Receptor, Biochemistry, vol. 34, No. 47, 1995, pp. 15407-15414.
Barak, L.S., et al.,Internal Trafficking and Surface Mobility of a Functionally Intact β2-Adrenergic Receptor- Green Fluorescent Protein Conjugate, Molecular Pharmacology, 51, 1997, pp. 177-184.
Barak, L.S., et al.,Real-time Visualization of the Cellular Redistribution of G Protein-coupled Receptor Kinase 2 and β-arrestin 2 during Homologous Desensitization of the Substance P Receptor, Journal of Biological Chemistry, vol. 274, No. 11, Mar. 12, 1999, pp. 7565-7569, The American Society for Biochemistry and Molecular Biology, Inc., USA.
Cubitt, A., et al.,Understanding, Improving and Using Green Fluorescent Proteins, Trends in Biochemical Sciences, International Union of Biochemistry and Molecular Biology, 448-455, Elsevier Trends Journals, Oxford, UK.
Drews, J.,Drug Discovery: A Historical Perspective, Science, vol. 287, Mar. 17, 2000, pp. 1960-1964, American Association for the Advancement of Science, Washington, D.C.
Ferguson, S.S.G., et al.,G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins, Can. J. Physiol. Pharmacol., vol. 74, 1996, pp. 1095-1110, NRC, Canada.
Ferguson, S.S.G.,Molecular Mechanisms of G Protein-Coupled Receptor Desensitization and Resensitization, Life Sciences, XP-002076355, vol. 62, pp. 1561-1565, 1998, Elsevier Publication, USA.
Ferguson, S.S.G., et al.,Role of Phosphorylation in Agonist-promoted β2-Adrenergic Receptor Sequestration, Journal of Biological Chemistry, vol. 270, No. 42, Oct. 20, 1995, pp. 24782-24789, The American Society for Biochemistry and Molecular Biology, Inc., USA.
Ferguson, S.S.G., et al.,Role of β-arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization, Science, vol. 271, Jan. 19, 1996, pp. 363-366.
Grady, E., et al.,Mechanisms Attenuating Cellular Responses to Neuropeptides: Extracellular Degradation of Ligands and Desensitization of Receptors, The Journal of Investigative Dermatology Symposium Proceedings, vol. 21, No. 1, pp. 69-75, Aug. 1997, The Society of Investigative Dermatology, Inc.
Harris, E., et al,Protein Purification Methods, pp. 12-18, 1989, Oxford University Press, New York, U.S.
Hausdorff, W.P., et al.,A Mutation of the β2-Adrenergic Receptor Impairs Agonist Activation of Adenylyl Cyclase without Affecting High Affinity Agonist Binding, Journal of Biological Chemistry, vol. 265, No. 3, Jan. 25, 1990, pp. 1388-1393, The American Society for Biochemistry and Molecular Biology, Inc., USA.
Kim, K.-M., et al.,Differential Regulation of the Dopamine D2and D3Receptors by G Protein-coupled Receptor Kinases and β-arrestins, Journal of Biological Chemistry, vol. 276 No. 40, Oct. 5, 2001, pp. 37409-97
Barak Lawrence S.
Caron Marc G.
Laporte Stephane A.
Oakley Robert H.
Brezner David J.
Dorsey & Whitney
Molecular Devices Corporation
Ulm John
LandOfFree
Methods of screening compositions for G protein-coupled... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of screening compositions for G protein-coupled..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of screening compositions for G protein-coupled... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3813071