Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-05-15
2007-05-15
Sullivan, Daniel M. (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007240, C435S007400, C435S377000
Reexamination Certificate
active
11140275
ABSTRACT:
A method of screening cellular polypeptides for pro-apoptotic or anti-apoptotic activity in a cell of a particular cell-type by: (a) culturing cells of the particular cell-type under non apoptotic conditions and culturing cells of the particular cell-type under apoptotic conditions, and (b) determining subcellular localization of the cellular polypeptides in the cultured cells, wherein a localization of a cellular polypeptide in lipid rafts in cultured cells under non apoptotic conditions and a segregation of the cellular polypeptide from lipid rafts in cultured cells under apoptotic conditions is indicative that the cellular polypeptide has a pro-apoptotic or an anti-apoptotic activity in the particular cell-type.
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Ayllon Veronica
Cayla Xavier
Fleischer Aarne
Garcia Alphonse
Rebollo Angelita
Centre National de la Recherche Scientifque
Consejo Superior de Investigaciones Cientificas
Institut Pasteur
McGillem Laura
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
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