Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2011-03-01
2011-03-01
Gitomer, Ralph (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
C800S020000, C424S009200
Reexamination Certificate
active
07897363
ABSTRACT:
The present invention provides methods of screening an agent for an activity in an isolated organ, e.g., eye, from a teleost, e.g., zebrafish. Methods of isolating eyes from zebrafish are provided. Methods of screening an agent for an ocular activity in the isolated eye are provided. Methods of screening an agent for an ocular activity in a model of ocular disease or disorder are provided. Methods of screening an agent for an ocular activity in the isolated eye and for screening the agent for cell death and/or toxic activity in the eye or other organ or tissue are provided. The invention further provides high throughput methods of screening agents for an activity in isolated eyes of zebrafish in multi-well plates.
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patent: 7176189 (2007-02-01), Baranowitz
patent: 2002/0187921 (2002-12-01), Rubeinstein
patent: 2005/0079577 (2005-04-01), Ashkenazi et al.
patent: 2006/0123487 (2006-06-01), Serbedzija et al.
PCT International Search Report and Written Opinion of Aug. 20, 2008 for Application No. PCT/US2008/066760.
McGrath Patricia
Seng Wen Lin
Gitomer Ralph
Hamilton, Brooks, Smith & Reynolds, P.C.
Phylonix Pharmaceuticals, Inc.
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