Methods of screening agents, conjugates or conjugate...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007210, C435S069100, C435S252300

Reexamination Certificate

active

06955888

ABSTRACT:
The invention provides methods of screening agents, conjugates or conjugate moieties, linked or linkable to agents, for capacity to be transported as substrates through the PEPT2 transporter. The invention also provides methods of treatment involving delivery of agents that either alone, or as a result of linkage to a conjugate moiety, are substrates of the PEPT2 transporter. The invention also provides conjugates comprising a pharmaceutical agent which is linked to a conjugate moiety that is a substrate for a PEPT2 transporter.

REFERENCES:
patent: 5710018 (1998-01-01), Dantzig et al.
Ayala FJ and Kiger Jr JA. Modern Genetics. p 45-48. James W. Behnke, ed. The Benjamin/Cummings Publishing Co., Menlow Park, CA, 1980.
Rieger R. et al. Glossary of Genetics:Classical and Molecular. 5thed. p 16-17, Springer-Verlag, New York, 1991.
Liu W. et al. Biochimica et Biophysica Acta 1235:461-466, 1995.
Liang R, et al. J. Biol. Chem. 270(12), 6456-6463, 1995.
Doring et al., “Delta-aminolevulinic Acid Transport by Intestinal and Renal Peptide Transporters and Its Physiological and Clinical Implications,”J. Clin. Invest.101(12):2761-2767 (1998).
Fei et al., Nature 368: 563-566 (1994).
Miyamoto et al., Biochimica et Biophysica Acta 1305:34-38 (1996).
Liu et al., Biochimica et Biophysica Acta 1235:461-466 (1995).
Boll et al., Prod. Natl. Acad. Sci. USA 93:284-289 (1996).
Saito et al., Biochimica et Biophysica Acta 1280:173-177 (1996).
Iseki et al., Intestinal Absorption of Several β-Lactam Antiobiotics, J. Pharm. Dyn., 7, 768-775 (1984).
Ganapathy et al., Differential Recognition of β-Lactam Antibiotics by Intestinal and Renal Peptide Transporters, PEPT 1 and PEPT 2, The Journal of Biological Chemistry, vol. 270, No. 43, Issue of Oct. 27, pp. 25672-25677, 1995.
Siamak A. Adibi, The Oligopeptide Transporter (PEPT-1) in Human Intestine: Biology and Function, Special Reports and Reviews, The American Gastroenterological Association, 1997.
Randall J. Mrsny, Oligopeptide Transporters as Putative Therapeutic Targets for Cancer Cells, Pharmaceutical Research, vol. 15, No. 6, 1998.
Terada et al., Recognition of β-Lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK Cells, 1997, The American Physiological Society.
Iseki et al., Multiplicity of the H+ -Dependent Transport Mechanism of Dipeptide and Anionic β-Lactam Antibiotic Ceftibuten in Rat Intestinal Brush-Border Membrane, The Journal of Pharmacology and Experimental Therapeutics, vol. 289, No. 1 (1999).
Kitagawa and Sugaya, Chaacteristics of Uptake of Cefroxadine by Rabbit Small Intestinal Brush Border Membrane Vesicles, Biol. Pharm. Bull. 19(2) 268-273 (1996).
Saitoh et al., Restricted Intestinal Absorption of Some β-Lactam Antibiotics by an Energy-Dependent Efflux System in Rat Intestine, Pharmaceutical Research, vol. 14, No. 5, 1997.
Otto and Bauer, Dipeptide Uptake: A Novel Marker for Testicular and Ovarian Macrophages, The Anatomical Record 245:662-667 1996.
Ganapathy and Liebach, Peptide Transporters, Department of Bochemistry and Molecular Biology, Medical College of Augusta, Georgia, pp. 395-400 (1996).
Zhu et al., Differential Recognition of ACE Inhibitors in Xenopus Laevis Oocytes Expressing Rat PEPT1 and PEPT2, Pharmaceutical Research, vol. 17, No. 5, 2000.
Ganapathy et al., Interaction of Anionic Cephalosporins with the Intestinal and Renal Peptide Transporters PEPT 1 and PEPT2, Biochimica et Biophysica Acta 1324 (1997) 296-308.
Fei et al., Preferential Recognition of Zwitterionic Dipeptides as Transportable Substrates by the High-Affinity Peptide Transporter PEPT2, Biochimica et Biophysica Acta 1418 (1999) 344-351.
Dixon and Mizen, Absorption of Amino Penicillins from Everted Rat Intestine, J. Physiol. (1977), 269, pp. 549-559.
Lee et al., Biopharmaceutics of Transmucosal Peptide and Protein Drug Administration: Role of Transport Mechanisms with a Focus on The Involvement of PEPT1, Journal of Controlled Release 62 (1999) 129-140.
Han et al., CHO/HPEPT1 Cells Overexpressing the Human Peptide Transporter (HPEPT1) as an Alternative in Vitro Model for Peptidomimetic Drugs, Journal of Pharmaceutical Sciences/vol. 88, No. 3, Mar. 1999.
Tamai et al., The Predominant Contributions of Oligopeptide Transporter PEPT1 to Intestinal Absorption of β-Lactam Antiobiotics in the Rat Small Intestine, J. Pharm. Pharmacol. 1997, 49; 796-801.
Ming et al., Human Dipeptide Transporter, Hpept1, Stably Transfected into Chinese Hamster Ovary Cells, Pharmaceutical Research, vol. 13, No. 11, 1996.
Teuscher et al., Functional Evidence for Presence of PEPT2 in Rat Choroid Plexus:Studies with Glycylsarcosine', The Journal of Pharmacology and Experimental Therapeutics, vol. 294, No. 2 (2000).
Terada et al., Characterization of Stably Transfected Kidney Epithelial Cell Line Expressing Rat H+/Peptide Contransporter PEPT1: Localization of PEPT1 and Transport of β-Lactam Antibiotics 1, The Journal of Pharmacology and Experimental Therapeutics, vol. 281, No. 3 (1997).
Gonzales et al., An Oligopeptide Transporter is Expressed at High Levels in the Pancreatic Carcinoma Cell Lines AsPc-1 and Capan-2 1, Cancer Research 58, 519-525. Feb. 1, 1998.
Inui et al., Physiological and Pharmacological Implications of Peptide Transporters, PEPT1 and PEPT2, Nephrology Dialysis Transplantation, Nephrol Dial Transplant (2000) 15 (Suppl 6): 11-13.
Tamai et al., Functional Expression of Transporter for β-Lactam Antibiotics and Dipeptides in Xenopus Laevis Oocytes Injected with Messenger RNA from Human, Rat and Rabbit Small Intestines 1, The Journal of Pharmacology and Experimental Therapeutics, vol. 273, No.1 (1995).
Naasani et al., Comparison of the Transport Characteristics of Ceftibuten in Rat Renal and Intestinal Brush-Border Membranes, Biochimica et Biophysica Acta 1231 (1995) 163-168.
Dantzig et al., Association of Intestinal Peptide Transport with a Protein Related to the Cadherin Superfamily, Science, vol. 264, Apr. 15, 1994.
Yuasa et al., Peptide Carrier-Mediated Transport in Intestinal Brush Border Membrane Vesicles of Rats and Rabbits: Cephradine Uptake and Inhibition, Pharmaceutical Research, vol. 10, No. 3, 1993.
Inui et al., Transepithelial Transport of oral Cephalosporins by Monolayers of Intestinal Epithelial Cell Line Caco-2: Specific Transport Systems in Apical and Basolateral Membranes: The Journal of Pharmacology and Experimental Therapeutics, vol. 261, No. 1 (1992).
Iseki et al., Comparison of Transport Characteristics of Amino β-Lactam Antibiotics and Dipeptides Across Rat Intestinal Brush Border Membrane, J. Pharm. Pharmacol. 1989, 41:628-632.
Dantzig and Bergin, Carrier-Mediated Uptake of Cephalexin in Human Intestinal Cells, Biochemical and Biophysical Research Communications, pp. 1082-1087, vol. 155, No. 2, 1988.
Meredith and Boyd, Structure and Function of Eurkryotic Peptide Transporters, CMLS Cellular and Molecular Life Sciences, CMLS, Cell. Mol. Life Sci. 57 (2000) 754-778.
Ogihara et al., Immuno-Localization of H +/Peptide Cotransporter in Rat Digestive Tract, Biochemical and Biophysical Research Communications 220 848-852 (1996).
Leibach and Ganapathy, Peptide Transporters in the Intestine and the Kidney, Annu. Rev. Nutr. 1996. 16:99-119.

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