Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Transferases
Patent
1997-05-27
1999-06-29
Witz, Jean C.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Transferases
424 946, 424 9461, 424 9462, 424 9463, 424 9464, 424 9465, 424 9466, A61K 3846
Patent
active
059165570
ABSTRACT:
The present invention relates to the use of an ECM-altering enzymatic activity, such as a proteoglycanase or a protease, to stimulate the generation of cartilage tissue by inducing chondrocytes to synthesize new cartilage matrix. It has been discovered that treating chondrocytes with an enzymatic activity that modifies the territorial ECM of the cell, especially cell surface proteoglycans, can in and of itself be sufficient to stimulate cartilage production by the chondrocytes. The subject invention can be employed therapeutically to correct or prevent degeneration of connective tissue. For instance, the present method can be used in the treatment of disorders comprising cartilage such as found in an diarthroidal joint (e.g. articular and interarticular cartilage), as well as in the treatment of tendon and ligamental tissues. Such disorders can range from chronic degeneration brought about by disease, overuse, or trauma, to plastic or reconstructive surgery. Moreover, the subject method may also be applied to both the development and implantation of prosthetic devices.
REFERENCES:
patent: 4280954 (1981-07-01), Yannas et al.
patent: 4350629 (1982-09-01), Yannas et al.
patent: 4448718 (1984-05-01), Yannas et al.
patent: 4458678 (1984-07-01), Yannas et al.
patent: 4505266 (1985-03-01), Yannas et al.
patent: 4553272 (1985-11-01), Mears
patent: 4696816 (1987-09-01), Brown
patent: 4787900 (1988-11-01), Yannas
patent: 4846835 (1989-07-01), Grande
patent: 4935497 (1990-06-01), Veis et al.
patent: 5041138 (1991-08-01), Vacanti et al.
patent: 5116374 (1992-05-01), Stone
patent: 5158574 (1992-10-01), Stone
patent: 5206023 (1993-04-01), Hunziker
patent: 5226914 (1993-07-01), Caplan et al.
Benjamin et al., "Research Review. Fibrocartilage" J. Anat., vol. 171, pp. 1-15, 1990.
Bertolami et al., "Use of Sodium Hyaluronate in Treating Temporomandibular Joint Disorders: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial," J. Oral Maxillofac. Surg., vol. 51, pp. 232-242, 1993.
Craig et al., "A Role for Hyaluronan in Joint Development" J. Anat., vol. 171, pp. 17-23, 1990.
Daniels et al., "Modulation of chondrogenesis by the cytoskeleton and extracellular matrix" Journal of Cell Science vol. 100, pp. 249-254, 1991.
Duke et al., "Studies of Chondrogenesis in Rotating Systems" Journal of Cellular Biochemistry., vol. 51, pp. 274-282, 1993.
Eurell et al., "The Effects of Chondroitinase ABC on the Rabbit Intervertebral Disc" Clinical Orthopaedics and Related Research., No. 256, pp. 238-243, Jul. 1990.
Glowacki et al., "Tissue Response to Bone-Derived Implants" Bone Grafts & Bone Substitutes, Chapter 8, pp. 84-92.
Ishiguro et al., "Immunolocation of Atypical Chondroitin Sulfate Chains Reacting with the 3-B-3 Monoclonal Antibodies Following Chymopapain-Induced Injury in the Rabbit" Department of Biochemistry, Anatomy and Internal Medicine (Section of Rheumatology). Rush Medical College at Rush-Presbyterian-St. Luke's Medical Center, Chicago IL 60612.
Kato et al., "Experimental Chemonucleolysis With Chondroitinase ABC" Clinical Orthopaedics and Related Research, No. 253, pp. 301-308, Apr. 1990.
Koob et al., "Effects of Chondroitinase-ABC on Proteoglycans and Swelling Properties of Fibrocartilage in Bovine Flexor Tendon" Journal of Orthopaedic Research, vol. 7, No. 2, pp. 219-227, 1989.
Labat-Robert et al., "Extracellular matrix" FEBS, vol. 268, No. 2, pp. 386-393, Aug. 1990.
Langer et al., "Tissue Engineering" Science, vol. 260, pp. 920-926, May 14, 1993.
McDevitt et al., "Ultrastructure and Biochemistry of Meniscal Cartilage" Clinical Orthopaedics and Related Research, No. 252, pp. 8-18, Mar. 1990.
Mizuno et al., "A Collagen/DBP Spong eSystem Designed for In Vitro Analysis of Chondroinduction" Mat. Res. Soc. Symp. Proc., vol. 252, pp. 133-140, 1992.
Morris-Kay et al., "Immunohistochemical localisation of chondroitin sulphate proteoglycans and the effects of chondroitinase ABC in 9-to 11-day rat embryos" Development, vol. 106, pp. 787-798, 1989.
Mow et al., "Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures" Biomaterials, vol. 13, No. 2, pp. 67-97, 1992.
Olmarker et al., "Effects of Chondroitinase ABC on ntrathecal and Peripheral Nerve Tissue. An in Vivo Experimental Study on Rabbits" Spine, vol. 16, No. 1, pp. 43-45, 1991.
Olmarker et al., "Microvascular Effects of Chondroitinase ABC and Chymopapain. An In Vivo Experimental Study on Hamsters and Rabbits" Clinical Orthopaedics and Related Research, No. 257, pp. 274-279, Aug. 1990.
Ratcliffe et al., "The Quantitation of Native Chondroitin Sulfate Epitope in Synovial Fluid Lavages and Articular Cartilage from Canine Experimental Osteoarthritis and Disuse Atrophy" Arthritis and Rheumatism, vol. 36, No. 7, pp. 1-9, 1993.
Ratcliffe et al., "Increased concentrations of proteoglycan components in the synovial fluids of patients with acute but not chronic joint disease" Annals of the Rheumatic Diseases, vol. 47, pp. 826-832, 1988.
Sampath et al., "In vitro transformation of mesenchymal cells derived from embryonic muscle into cartilage in response to extracellular matrix components of bone" Proceedings of the National Academy of Sciences, vol. 81, pp. 3419-3423, 1984.
Wiig et al., "The Early Effect of High Molecular Wieght by Hyaluronan (Hyaluronic Acid) on Anterior Cruciate Ligament Healing: An Experimental Study in Rabbits" Journal of Orthopaedics Research, vol. 8, pp. 425-434, 1990.
Williams et al., "repair of Articular Cartilage Injury Following Intra-Articular Chymopapain-Induced Matrix Proteoglycan Loss" Journal of Orthopaedic Research, vol. 11, pp. 705-716, 1993.
Yamagata et al., "Regulation of Cell-Substrate Adhesion by Proteoglycans Immobilized on Extracellular Substrates" The Journal of Biological Chemistry, vol. 264, No. 14, pp. 8012-8018, 1989.
Miyazaki et al., Japanese Journal of Human Genetics 35(2): 215-221 (1990).
Chandrasekar et al., Matrix 12(1): 1-10 (1992).
Vogel et al., Biochem J 223(3): 587-598 (1984).
Berlowitz-Tarrant Laurence
Mizuno Shuichi
Ratcliffe Anthony
International Technology Management Associates, Ltd.
The Trustees of Columbia University in the City of New York
White John P.
Witz Jean C.
LandOfFree
Methods of repairing connective tissues does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of repairing connective tissues, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of repairing connective tissues will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1373766