Methods of regulating skin appearance with vitamin B3 compound

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice

Reexamination Certificate

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Details

C424S070100, C514S356000, C514S458000, C514S725000, C514S844000, C514S847000, C514S887000, C514S944000

Reexamination Certificate

active

06238678

ABSTRACT:

TECHNICAL FIELD
The present invention relates to topical compositions containing a vitamin B
3
compound for regulating the condition of skin, especially for regulating visible and/or tactile discontinuities in skin associated, e.g., with skin aging. Preferred compositions contain niacinamide.
BACKGROUND OF THE INVENTION
Many personal care products currently available to consumers are directed primarily to improving the health and/or physical appearance of the skin. Among these skin care products, many are directed to delaying, minimizing or even eliminating skin wrinkling and other histological changes typically associated with the aging of skin or environmental damage to human skin.
Skin is subject to insults by many extrinsic and intrinsic factors. Extrinsic factors include ultraviolet radiation (e.g., from sun exposure), environmental pollution, wind, heat, low humidity, harsh surfactants, abrasives, and the like. Intrinsic factors include chronological aging and other biochemical changes from within the skin. Whether extrinsic or intrinsic, these factors result in visible signs of skin aging and environmental damage, such as wrinkling and other forms of roughness (including increased pore size, flaking and skin lines), and other histological changes associated with skin aging or damage. To many people, skin wrinkles are a reminder of the disappearance of youth. As a result, the elimination of wrinkles has become a booming business in youth-conscious societies. Treatments range from cosmetic creams and moisturizers to various forms of cosmetic surgery.
Extrinsic or intrinsic factors may result in the thinning and general degradation of the skin. For example, as the skin naturally ages, there is a reduction in the cells and blood vessels that supply the skin. There is also a flattening of the dermal-epidermal junction which results in weaker mechanical resistance of this junction. See, for example, Oikarinen, “The Aging of Skin: Chronoaging Versus Photoaging,”
Photodermatol. Photoimmunol. Photomed
., vol. 7, pp. 3-4, 1990, which is incorporated by reference herein in its entirety.
It has now been found that vitamin B
3
compounds, including niacinamide, provide benefits in regulating skin condition previously unrecognized in the art of which the present inventors are aware. For example, topical niacinamide can regulate the signs of skin aging, e.g., reduce or efface the visibility of the fine lines, wrinkles, and other forms of uneven or rough surface texture associated with aged or photo damaged skin. It has also now been found that topical compositions containing a vitamin B
3
compound and a retinoid provide benefits in regulating skin condition previously unrecognized in the art of which the present inventors are aware. For example, such compositions enable the regulation of signs of skin aging with decreased potential for retinoid dermatitis. In addition, the vitamin B
3
compound in combination with certain retinoids synergistically regulates signs of skin aging, especially visible and/or tactile discontinuities in skin texture associated with aged skin, including fine lines and wrinkles.
It is therefore an object of the present invention to provide topical compositions for prophylactically and/or therapeutically regulating mammalian skin condition (especially of human skin, more especially facial skin), containing a vitamin B
3
compound, especially niacinamide.
It is another object of the present invention to provide topical compositions for prophylactically and/or therapeutically regulating signs of mammalian skin aging, containing a vitamin B
3
compound, especially niacinamide.
It is another object of the present invention to provide topical compositions for prophylactically and/or therapeutically regulating visible and/or tactile discontinuities in mammalian skin texture, including fine lines, wrinkles, enlarged pores, roughness, dryness and other skin texture discontinuities associated with aged skin, containing a vitamin B
3
compound, especially niacinamide.
It is another object of the present invention to provide topical compositions for skin moisturization, photoprotection and skin lightening comprising a vitamin B3 compound and a second pharmaceutical active.
Other objects of the present invention are to provide such topical compositions further comprising a retinoid.
The present invention also relates to methods of providing such regulation using the subject compositions.
The present invention further relates to methods of providing skin moisturization, photoprotection and skin lightening.
These and other objects of this invention will become apparent in light of the following disclosure.
SUMMARY OF THE INVENTION
The present invention relates to regulation of skin condition involving the topical application of a composition containing a vitamin B
3
compound, especially niacinamide. The present invention also relates to regulation of skin condition involving topical application of a composition containing a vitamin B
3
compound, especially niacinamide, and a retinoid. The invention especially relates to regulation of signs of skin aging, more especially regulating visible and/or tactile discontinuities in mammalian skin texture, including discontinuities associated with aged skin, involving the topical application of such compositions. The present invention relates to both prophylactic and therapeutic regulation of skin condition.
In preferred embodiments, the vitamin B
3
compound is substantially free of the salt form and is uncomplexed, the vitamin B
3
compound is niacinamide, and the carrier contains a hydrophilic diluent.
DETAILED DESCRIPTION OF THE INVENTION
All percentages and ratios used herein are by weight of the total composition and all measurements made are at 25° C., unless otherwise designated.
The compositions of the present invention can comprise, consist essentially of, or consist of, the essential as well as optional ingredients and components described herein. As used herein, “consisting essentially of” means that the composition or component may include additional ingredients, but only if the additional ingredients do not materially alter the basic and novel characteristics of the claimed compositions or methods.
All publications cited herein are hereby incorporated by reference in their entirety.
The term “topical application”, as used herein, means to apply or spread the compositions of the present invention onto the surface of the skin.
The term “dermatologically-acceptable,” as used herein, means that the compositions or components thereof so described are suitable for use in contact with human skin without undue toxicity, incompatibility, instability, allergic response, and the like.
The term “safe and effective amount” as used herein means an amount of a compound or composition sufficient to significantly induce a positive benefit, preferably a positive skin appearance or feel benefit, including independently the benefits disclosed herein, but low enough to avoid serious side effects, i.e., to provide a reasonable benefit to risk ratio, within the scope of sound judgment of the skilled artisan.
The compositions of the present invention are useful for topical application and for regulating skin condition, including visible and/or tactile discontinuities in skin (especially the skin surface; such discontinuities are generally undesired). Such discontinuities may be induced or caused by internal and/or external factors, and include the signs of skin aging described herein. “Regulating skin condition” includes prophylactically regulating and/or therapeutically regulating skin condition, including visible and/or tactile discontinuities in skin. As used herein, prophylactically regulating skin condition includes delaying, minimizing and/or preventing visible and/or tactile discontinuities in skin. As used herein, therapeutically regulating skin condition includes ameliorating, e.g., diminishing, minimizing and/or effacing, discontinuities in skin. Regulating skin condition involves improving skin appearance and/or feel.
The compos

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