Methods of receptor modulation and uses therefor

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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536 264, 536 2644, A61K 3168, C12P 1942

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active

058694650

ABSTRACT:
Receptor modulating agents capable of modulating cell surface receptors by affecting the cell surface receptor trafficking pathway are utilized for the treatment and diagnosis of a variety of disorders in warm-blooded animals, including neoplastic disorders. The receptor modulating agents are comprised of a covalently bound rerouting moiety and targeting moiety.

REFERENCES:
patent: 5196510 (1993-03-01), Rodwell et al.
patent: 5294536 (1994-03-01), Palumbo
patent: 5310656 (1994-05-01), Pourfarzaneh et al.
patent: 5428023 (1995-06-01), Russell et al.
patent: 5538901 (1996-07-01), Law et al.
patent: 5548064 (1996-08-01), Russell et al.
patent: 5574018 (1996-11-01), Habberfield et al.
patent: 5589463 (1996-12-01), Russell et al.
Kraautler, Bernhard, et al., "Oligomethylene-Bridged Vitamin B.sub.12 Dimers," Angewandt Chemie International Edition English, vol. 34, No. 1, 1995, pp. 84-86.
Takahashi, Kiyoshi, et al., "Receptor Binding and Internalization of Immobilized Transcobalamin II by Mouse Leukaemia Cells," Nature, vol. 288, No. 18, Dec. 1980, pp. 713-715.
Mclean et al. `Analogs Of Cobalamin in Habit The Growth Of Lekemia In Vitro` pp. 1-20.
Pathare et al. `Synthesis Of Cobalamin Dimers Using Isophthalate Crosslinking Of Corrin Ring Carboxylates And Evaluation Of Their Binding To Transcobalamin`, Bioconjugate Chem. vol. 8, No. 2, pp. 161-172, 1997.
Pignatello, Joseph J., et al., "Self-Association of Organocobalamins in Aqueous Solution," J. Chem. Soc. Dalton Trans., 1985 pp. 1381-1386.

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