Methods of promoting osteogenesis

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S254090, C514S330000, C514S407000, C514S438000, C514S442000, C514S474000

Reexamination Certificate

active

10651934

ABSTRACT:
The invention is directed to methods of bone healing by administering a p38 MAP kinase inhibitor. The invention is directed to methods of treating bone fractures, bone diseases, bone grafting, especially enhancing bone healing following facial reconstruction, maxillary reconstruction, mandibular reconstruction or tooth extraction, enhancing long bone extension, enhancing prosthetic ingrowth, and increasing bone synostosis by administering a p38 MAP kinase inhibitor.

REFERENCES:
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4619652 (1986-10-01), Eckenhoff et al.
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 6410540 (2002-06-01), Goehring et al.
patent: 2356263 (2000-07-01), None
patent: WO96/21452 (1996-07-01), None
patent: WO96/21654 (1996-07-01), None
patent: WO96/40143 (1996-12-01), None
patent: WO97/25046 (1997-07-01), None
patent: WO97/35856 (1997-10-01), None
patent: WO98/25619 (1998-06-01), None
patent: WO98/56377 (1998-12-01), None
patent: WO98/57966 (1998-12-01), None
patent: WO99/32110 (1999-07-01), None
patent: WO99/32121 (1999-07-01), None
patent: WO99/32463 (1999-07-01), None
patent: WO99/57101 (1999-11-01), None
patent: WO99/61440 (1999-12-01), None
patent: WO99/64400 (1999-12-01), None
patent: WO 00/10563 (2000-03-01), None
patent: WO 00/12074 (2000-03-01), None
patent: WO 00/17204 (2000-03-01), None
patent: WO 00/19824 (2000-04-01), None
patent: WO 00/26209 (2000-05-01), None
patent: WO 00/41698 (2000-07-01), None
patent: WO 00/64422 (2000-11-01), None
patent: WO 00/71535 (2000-11-01), None
patent: WO 01/05749 (2001-01-01), None
patent: WO 01/10865 (2001-02-01), None
patent: WO 01/38324 (2001-05-01), None
patent: WO 01/64679 (2001-09-01), None
patent: WO 01/66539 (2001-09-01), None
patent: WO 01/66540 (2001-09-01), None
patent: WO 02/07772 (2002-01-01), None
De Laszlo et al. “Pyrroles and Other Heterocycles as Inhibitors of P38 Kinase”, Bioorganic & Medicinal Chemistry Letters vol. 8, pp. 2689-2694 (1998).
Tuli et al., “p38 MAP Kinase Regulation of AP-2 Binding in TGF-beta 1-Stimulated Chrondrogenesis of Human Trabecular Bone-Derived Cells”, Annals of New Yorks Academy of Science, vol. 961, pp. 172-177 (2002).
International Search Report for PCT/US03/26839, mailed on Aug. 16, 2004, 4 pages.
Adams et al., Bioorg. Med. Chem. Lett., 8:3111-3116 (1998).
Adler, Bone Diseases, p. 114(Springer-Verlag, Germany 2000).
Bell et al., J. Physiol., 100:299-317 (1941).
Bonnarens and Einhorn, J. Orthop. Res., 2:97-101 (1984).
Collis et al., Bioorg. Med. Chem. Lett., 11:693-696 (2001).
De Laszlo et al., Bioorg. Med. Chem. Lett., 8:2698 (1998).
Engesaeter et al., Acta Orthop. Scand., 49:512-518 (1978).
Fijen et al., Clin. Exp. Immunol., 124:16-20 (2001).
Gallagher et al., Bioorg. Med. Chem., 5:49-64 (1997).
Jiang et al., J. Biol. Chem., 271:17920-17926 (1996).
Kimble et al., Endocrinol., 136:3054-3061 (1995).
Kumar et al., Biochem. Biophys. Res. Comm., 235:533-538 (1997).
Lee et al., Bone, 30(1):71-77 (2002).
Li et al., Biochem. Biophys. Res. Comm., 228:334-340 (1996).
Li et al., Endocrinology, 143:3105-3113 (2002).
Matsumoto et al., FEBS Lett., 486:23-28 (2000).
Matsumoto et al., J. Biol. Chem., 275:31155-31161 (2000).
McLay et al., Bioorg. Med. Chem., 9:537-554 (2001).
Poste, Meth. Cell Biol. 14:33-71 (1976).
Report of a World Health Oraganization Study Group, World Health Organization Technical Series 843, “Assessment of a Fracture Risk and its Application to Screening for Postmenopausal Osteoporosis” (1994).
Revesz et al., Bioorg. Med. Chem. Lett., 10:1261-1264 (2000).
Simon et al., J. Bone Miner. Res., 17:963-976 (2002).
Stein et al., J. Biol. Chem. 272:19509-19517 (1997).
Wadsworth et al., J. Pharmacol. Expt. Therapeut., 291:680-687 (1999).
Wang et al., J. Biol. Chem., 272:23668-23674 (1997).
Wang et al., J. Biol. Chem., 273:2161-2168 (1998).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods of promoting osteogenesis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of promoting osteogenesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of promoting osteogenesis will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3742179

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.