Methods of promoting bone growth in mammals comprising administr

Details Methods of promoting bone growth in mammals comprising administr Methods of promoting bone growth in mammals comprising administr

1993-09-13

1995-10-10

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, 530324, 530399, 435 697, 435 694, 514 13, C07K 700, C07K 14635, A61K 3800, A61K 3829

Patent

active

054570921

ABSTRACT:
pPTH, bPTH or hPTH is modified by deletions from the natural C- and/or N-terminus. The modified compounds are useful active ingredients in therapeutic compositions. The therapeutic compositions do not stimulate renal adenylate cyclase but, rather, effect chondrocyte proliferation, that is to say, they exhibit a mitogenic and bone-specific effect.

REFERENCES:
Schluter et al. 1989. J. Biol. Chem. 264:11087-11092.
Somjen et al. 1990. Biochem. J. 272:781-785.
Slovik et al. 1986. J. Bone Min. Res. 1:377-381.
Somjen et al. 1991, Biochem. J. 277:863-868.
Potts et al. 1982. Adv. Prot. Chem. 35:323-389.

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