Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-09-15
2010-02-23
Duffy, Patricia A (Department: 1645)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S069700, C435S070100, C435S071100, C435S071200
Reexamination Certificate
active
07666621
ABSTRACT:
A novel surface exposed protein ofHaemophilus influenzaeor relatedHaemophilusspecies is described. The protein named protein D is an Ig receptor for human IgD and has an apparent molecular weight of 42,000. Protein D can be detected in all of 116 encapsulated and non-encapsulated isolates ofH. influenzaestudied. The protein from all strains shows in addition to the same apparent molecular weight immunogenic similarities since protein D from all strains interacts with three different mouse monoclonal antibodies and monoclonal human IgD. A method for purification of protein D is described. Cloning of the protein D gene fromH. influenzaeinE. coliis described as well as the nucleotide sequence and the deduced amino acid sequence.
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Duffy Patricia A
Finnegan Henderson Farabow Garrett & Dunner LLP
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