Methods of producing phosphitylated compounds

Details Methods of producing phosphitylated compounds Methods of producing phosphitylated compounds

2005-05-17

2005-05-17

Crane, L. E. (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

Reexamination Certificate

active

06894158

ABSTRACT:
Provided are methods of producing phosphitylated compounds, including 3′-O-phosphoramidites, comprising the step of reacting a hydroxyl-containing compound with a phosphitylating agent in the presence of a phosphitylation activator selected from the group consisting of: (1) acid-base complexes derived from an amine base of Formula Iwherein R, R1, and R2are independently C1-C10alkyl, C3-C10cycloalkyl, C6-C10aryl, C7-C10aralkyl, C1-C10heteroalkyl, or C1-C10heteroaryl, wherein any two adjacent R, R1, and R2may be connected to form a heterocyclic ring; (2) acid-base complexes derived from a diazabicyclo amine base; and (3) combinations of two or more thereof.

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