Methods of producing carboxylic acid ester derivatives and inter

Details Methods of producing carboxylic acid ester derivatives and inter Methods of producing carboxylic acid ester derivatives and inter

1995-05-18

1997-02-04

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549409, 549434, 549445, 549462, 568746, 568647, 568643, 568642, 568442, C07D31918, C07D31748, C07D31104

Patent

active

055999522

ABSTRACT:
Methods of producing carboxylic acid ester derivatives of formulae (I) and (II), which are useful, for instance, as intermediates for producing an anti-hypercholesterolemic agent having an inhibitory effect on HMG-CoA Reductase: ##STR1## wherein R.sup.1 and R.sup.2 are independently a protective group for hydroxyl group, or R.sup.1 and R.sup.2 integrally constitute a protective group for hydroxyl groups; R.sup.3 is an alkyl group, or an aryl group; and R.sup.4 is a substituted aryl group, a substituted heterocyclic group, a substituted vinyl group, or a substituted cycloalkenyl group; and ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are respectively the same as defined in the above formula (I), are disclosed. In addition, intermediates for use in these methods of producing the carboxylic acid ester derivatives are disclosed.

REFERENCES:
Jendralla et al., Synthesis, 1990, pp. 827-833.

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