Methods of producing carboxylic acid ester derivatives and inter

Details Methods of producing carboxylic acid ester derivatives and inter Methods of producing carboxylic acid ester derivatives and inter

1994-08-09

1996-01-02

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549333, 556437, 560 59, 560 60, C07D31906, C07C 69616

Patent

active

054810094

ABSTRACT:
Methods of producing carboxylic acid ester derivatives of formulae (I) and (II), which are useful, for instance, as intermediates for producing an anti-hypercholesterolemic agent having an inhibitory effect on HMG-CoA Reductase: ##STR1## wherein R.sup.1 and R.sup.2 are independently a protective group for hydroxyl group, or R.sup.1 and R.sup.2 integrally constitute a protective group for hydroxyl groups; R.sup.3 is an alkyl group, or an aryl group; and R.sup.4 is a substituted aryl group, a substituted heterocyclic group, a substituted vinyl group, or a substituted cycloalkenyl group; and ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are respectively the same as defined in the above formula (I), are disclosed. In addition, intermediates for use in these methods of producing the carboxylic acid ester derivatives are disclosed.

REFERENCES:
patent: 5049577 (1991-09-01), Varma et al.
J. Med. Chem., 1987, vol. 30, pp. 1858-1873, Clayton N. Heathcock, et al., "Total Synthesis and Biological Evaluation of Structural Analogues of Compactin and Dihydromevinolin".
Tetrahedron Letters, vol. 28, No. 13, pp. 1385-1388, 1987, J. E. Lynch, et al., "Synthesis of an HMG-CoA Reductase Inhibitor; A Diastereoselective Aldol Approach".
Tetrahedron Letters, vol. 33,. No. 49, pp. 7525-7526, 1992, Tatsuya Mimani, et al., "A Novel Enantioselective Synthesis of HMG Co-A Reductase Inhibitor NK-104 and a Related Compound".
Tetrahedron Letters, vol. 31, No. 18, 1990, G. Wess, et al., "Stereoselective Synthesis of HR 780 A New Highly Potent HMG-CoA Reductase Inhibitor", pp. 2545-2548.

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