Methods of producing aminobutene derivatives

Details Methods of producing aminobutene derivatives Methods of producing aminobutene derivatives

1993-08-06

1997-04-01

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546146, 546153, 546169, 546193, 546194, 546195, 546197, 546201, 546203, 546205, 546207, 546212, 546214, 546220, 546233, 546242, 546244, 546246, 549 76, 549 77, 549419, 549450, 549452, 560 29, 560 31, 560160, 564123, 564161, 564192, 564209, 564215, 564224, C07C23300, C07D21168, C07D21136, C07D21722

Patent

active

056167113

ABSTRACT:
A method of producing an aminobutene derivative of formula (I) by allowing a butenol derivative of formula (II) to react with an amide derivative of formula (III) is disclosed. The aminobutene derivative of formula (I) can be deprotected to produce an aminobutene derivative of formula (I-1) or an aminobutene derivative of formula (I-2): ##STR1## The aminobutene derivative of formula (I-A) can also be deprotected to produce the aminobutene derivative of formula (I-B). Any or all of the above aminobutene derivatives are useful as intermediates for producing anti-ulcer drugs, and anti-ulcer drugs having an inhibitory effect on gastric acid secretion based on the antagonism against histamine H.sub.2 receptor.

REFERENCES:
patent: 4353828 (1982-10-01), Bey et al.
Journal of the Chemical Society, Perkin Transactions 1, vol. 1, No. 4, 1991, pp. 705-713, Jeremy Cooper, et al., "An Approach To Chiral Trisubstituted Pyrrolidines By Enolate Claisen Rearrangement of Azalactones Derived From Alpha-Amino Acids".

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