Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Inactivation or attenuation; producing viral subunits
Patent
1993-04-23
1997-03-11
Campell, Bruce R.
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
Inactivation or attenuation; producing viral subunits
4351723, 4353201, 536 231, 536 2372, 536 245, 935 8, 935 34, C12N 706, C07H 2104
Patent
active
056100507
ABSTRACT:
The invention relates to methods and compositions for inhibition of viral replication. In particular, termination of replication of hepatitis B virus is achieved by introducing into a target cell an antisense oligonucleotide having a sequence substantially complementary to an mRNA which is in turn complementary to a portion of the minus strand of a hepatitis viral genome, which portion encoding solely part or all of the terminal protein region of the viral polymerase.
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Blum Hubert E.
Galun Eithan
Liang Tsanyang
Wands Jack R.
Campell Bruce R.
The General Hospital Corporation
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