Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-04-10
2007-04-10
Kam, Chih-Min (Department: 1656)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S008100, C530S350000, C530S416000, C530S417000, C424S009100, C435S226000
Reexamination Certificate
active
10371725
ABSTRACT:
The present invention relates to use of Narp inhibitor in order to promote or enhance recovery from ischemic events, particularly focal ischemia of the central nervous system, as well as for preventing or diminishing chronic degenerative changes.
REFERENCES:
patent: 4341762 (1982-07-01), Haast
patent: 6307031 (2001-10-01), Lipps
patent: 6316602 (2001-11-01), Lipps
patent: 1101820 (2001-05-01), None
patent: WO9739133 (1997-10-01), None
patent: WO0075661 (2000-12-01), None
patent: WO0163293 (2001-08-01), None
Dodds et al., Neuronal Pentraxin Receptor, A Novel Putative Integral Membrane Pentraxin That Interacts with Neuronal Pentraxin 1 and 2 and Taipoxin-associated Calcium-building Protein 49.J. Biol. Chem. 272(34):21488-21494 (1997).
Fohlman et al., Taipoxin, an Extremely Potent Presynaptic Neurotixin from the Venom of the Australian Snake Taipan (Oxyuranus s. scutellatus).Eur. J. Biochem. 68:457-469 (1976).
Kirkpatrick et al., Biochemical Interactions of the Neuronal Pentraxins.J. Biol. Chem. 275(23):17786-17792 (2000).
Lipps, Isolation of subunits, α, β and γ of the complex taipoxin from the venom of Australian taipan snake (Oxyuranus s. scutellatus): characterization of β taipoxin as a potent mitogen.Toxicon. 38:1845-1854 (2000).
O'Brien et al., Synaptic Clustering of AMPA Receptors by the Extracellular Immediate-Early Gene Product Narp.Neuron. 23:309-323 (1999).
Tsui et al., Narp, a Novel Member of the Pentraxin Family, Promotes Neurite Outgrowth and Is Dynamically Regulated by Neuronal Activity.J. Neurosci. 16(8):2463-2478 (1996).
Alape-Giron et al., (1999), “Elapid Venom Toxins: Multiple Recruitments of Ancient Scaffolds,”Eur. J. Biochem., vol. 259, pp. 225-234 (Exhibit 1); and.
Tzeng et al., (Sep. 15, 1989), “Taipoxin-Binding Protein on Synaptic Membranes: Identification by Affinity Labeling,”Biochemical and Biophysical Research Communications, vol. 165, No. 2, pp. 689-694 (Exhibit 2).
Faerman Alexander
Idelson Gregory Hirsch
Kachalsky Sylvia G.
Astellas Pharma Inc.
Cooper & Dunham LLP
Kam Chih-Min
Quark Biotech, Inc.
White John P.
LandOfFree
Methods of preventing or treating brain ischemia or brain... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of preventing or treating brain ischemia or brain..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of preventing or treating brain ischemia or brain... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3789670