Methods of preventing and reducing the size of striae distensae

Details Methods of preventing and reducing the size of striae distensae Methods of preventing and reducing the size of striae distensae

1989-09-01

1992-07-28

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514725, A61K 3120

Patent

active

051341638

ABSTRACT:
Straie distensae lesions may be prevented and/or reduced in size by topically applying to the skin affected with the lesions an effective amount of retinoic acid, preferably by daily application in a dermatologically acceptable vehicle, such as a cream base, at a concentration of about 0.025 to 0.1 weight percent. When applied during the straie rubrae stage, the retinoic acid may be effective to prevent the formation of straie albae lesions, and when applied in either stage, the retinoic acid may be effective to reduce the width and depth of the lesions, with improved texture and softness.

REFERENCES:
patent: 4603146 (1986-07-01), Kligman
Chemical Abstracts 106:125,892 f (1987).
Thomas et al., "The Therapeutic Uses of Topical Vitamin A Acid,", Journal of the American Academy of Dermatology, 4:505-513 (1981).
A. Jarrett, "Striae Atrophicae" Journal of Applied Cosmetology 7:89-91 (Jul.-Sep. 1989).
M. L. Elson, "Treatment of Striae Distensae with Topical Tretinoin" Journal Dermatological Surgery and Oncology 16:267-270 (1990).
C. Bordier et al., "Rupture de Vergetures au Cours d'un Psoriasis Pustuleux Traite par Etretinate" Annals of Dermatology and Venereology 111:929-931 (1984).
P. Zheng et al., "Anatomy of Striae," British Journal of Dermatology, 112:185-193 (1985).

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