Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1995-06-06
1998-06-09
Jacobson, Dian C.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
424 9464, 435212, 4352523, 435359, C12N 121, C12N 510, C12N 964, C12N 1555
Patent
active
057632537
ABSTRACT:
Tissue plasminogen activator (t-PA) derivatives are produced in useful quantities using recombinant DNA techniques. Specific derivatives include amino acid deletion derivatives and amino acid substitution derivatives. A deletion derivative lacking the N-terminal first 68 amino acids is specifically exemplified having requisite t-PA characteristics. The invention disclosed thus enables the production of t-PA derivatives via recombinant means. Methods, expression vehicles and various host cells useful in the production of said t-PA derivatives are also disclosed.
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Goeddel David V.
Kohr William J.
Pennica Diane
Vehar Gordon A.
Dreger Walter H.
Genentech Inc.
Jacobson Dian C.
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