Methods of preparing polymers having terminal amine groups...

Details Methods of preparing polymers having terminal amine groups... Methods of preparing polymers having terminal amine groups...

2005-10-04

2009-10-13

Truong, Duc (Department: 1796)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Nitrogen-containing reactant

C528S486000, C525S054100, C525S403000

Reexamination Certificate

active

07601798

ABSTRACT:
The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal tosylate with a protected amine salt to form a polymer containing a terminal protected amine and thereafter deprotecting the polymer containing the terminal protected amine to form the polymer having a terminal amine. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.

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