Methods of preparing polymers having terminal amine groups

Details Methods of preparing polymers having terminal amine groups Methods of preparing polymers having terminal amine groups

2011-01-11

2011-01-11

Truong, Duc (Department: 1796)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From phosphorus-containing reactant

C528S004000, C528S394000, C528S422000, C528S425000, C528S480000, C528S487000, C528S488000, C528S492000, C528S495000

Reexamination Certificate

active

07868131

ABSTRACT:
The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal azide with a phosphine-based reducing agent such as triphenylphosphine or an alkali metal borohydride reducing agent such as sodium borohydride in a solvent to reflux. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.

REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4179339 (1979-12-01), Davis et al.
patent: 5206344 (1993-04-01), Katre et al.
patent: 6448369 (2002-09-01), Bentley et al.
patent: 6828401 (2004-12-01), Nho et al.
patent: 7301003 (2007-11-01), Zhao et al.
patent: 2003/0149307 (2003-08-01), Hai et al.
patent: 2337523 (1999-11-01), None
Supplementary European Search Report issued in European Patent Application No. 06802202.9 and dated Jun. 24, 2009.
Frisch, B., et al., “Synthesis of Short Polyoxyethylene-Based . . . ”, Bioconjugate Chem., vol. 7, p. 180-186, 1996.
Zalipsky, S., et al., Eur. Polym. J. 19:1177-1183, 1983.
Mutter, M., Tetrahedron Lett., 2839-2842, 1978.
Renil, M., et al., J. Peptide Sci., 195-210, 1998.
Mongondry, P., Macromol. Rapid Commun., 24:681-685, 1998.
Yinglin, H., Synth. Commun., 21:79-84, 1991.
Pal, B., Synth. Commun., 34:1317-1323, 2004.
Ragnarsson, U., Acc. Chem. Res., 24:285-289, 1991.
International Search Report and Written Opinion issued in PC/US06/32971 and dated Mar. 21, 2007.
European Search Report issued in European Patent Application No. 06 802 202.9 and dated May 3, 3010.

Affiliated with

Also associated with

Rating

Methods of preparing polymers having terminal amine groups does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of preparing polymers having terminal amine groups, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of preparing polymers having terminal amine groups will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2663853