Methods of preparing optically active epoxy alcohol

Details Methods of preparing optically active epoxy alcohol Methods of preparing optically active epoxy alcohol

1991-10-24

1993-05-25

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435198, 435280, C12P 1702, C12N 920, C07P 4100

Patent

active

052139751

ABSTRACT:
This invention relates to the methods of preparing optically active epoxy alcohol which is caracterized by the steps of adding carboxylic anhydride to racemic epoxy alcohol (formula 1) in the presence of a hydrolase in an organic solvent, esterifying (-)-form of the epoxy alcohol preferentially to be epoxy ester (formula 2), separating optically active epoxy ester (formula 2) from optically active epoxy alcohol (formula 3) to yield optically active epoxy alcohol (formula 4), so that epoxy alcohol (formula 1) in high purity can be obtained easily and safely at ordinary temperature. ##STR1##

REFERENCES:
patent: 4732853 (1988-03-01), Whitesides et al.
patent: 4923810 (1990-05-01), Walts et al.
patent: 4996158 (1991-02-01), Oda et al.
Biotech Abs. 91-194871/27 Nitto Denko Co. Fukusaki et al EP-435293 Jul. 1991.
J Am. Chem Soc. 1984, 106, 7250-7251, Ladner et al.
Tetrahedron Letters, vol. 29, No. 20, pp. 2455-2548, 1988, Bianchi et al.
Chem. Abstract, vol. 112, No. 19, May. 7, 1990, No. 177061 Aniano, Masita et al.

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