Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-12-02
1999-10-12
Campbell, Eggerton A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 243, 435 912, C12Q 168, C07H 2102, C12P 1934
Patent
active
059653639
ABSTRACT:
This invention relates to methods for screening nucleic acids for polymorphisms by analyzing amplified target nucleic acids using mass spectrometric techniques and to procedures for improving mass resolution and mass accuracy of these methods of detecting polymorphisms.
REFERENCES:
patent: 4775619 (1988-10-01), Urdea
patent: 4935357 (1990-06-01), Szybalski
patent: 5003059 (1991-03-01), Brennan
patent: 5064754 (1991-11-01), Mills
patent: 5075217 (1991-12-01), Weber
patent: 5288644 (1994-02-01), Beavis et al.
patent: 5364759 (1994-11-01), Caskey et al.
patent: 5369004 (1994-11-01), Polymeroulos et al.
patent: 5378602 (1995-01-01), Polymeroulos et al.
patent: 5464985 (1995-11-01), Cornish et al.
patent: 5468610 (1995-11-01), Polymeroulos et al.
patent: 5503980 (1996-04-01), Cantor
patent: 5508169 (1996-04-01), Deugau et al.
patent: 5547835 (1996-08-01), Koster
patent: 5580733 (1996-12-01), Levis et al.
patent: 5582979 (1996-12-01), Weber
patent: 5599666 (1997-02-01), Schumm et al.
patent: 5605798 (1997-02-01), Koster
patent: 5622824 (1997-04-01), Koster
patent: 5625184 (1997-04-01), Vestal et al.
patent: 5626184 (1997-05-01), Vestal et al.
patent: 5627369 (1997-05-01), Vestal et al.
patent: 5691141 (1997-11-01), Koster
patent: 5700642 (1997-12-01), Monforte et al.
Arnott et al., "Construction and performance of a laser desorption/ionization TOF mass spectrometer system: applications to problems in peptide, protein, and DNA structural analysis," The 40th ASMS Conference on Mass Spectrometry and Allied Topics, May 31-Jun. 5, Washington, D.C., pp. 328-329, 1992.
Bevan et al., "The analysis of oligonucleotides and their phosphoramidate analogues by LSIMS mass spectrometry," The 39th ASMS Conference on Mass Spectrometry and Allied Topics, pp. 983-984, 1989.
Edmonds et al., "Electrospray ionization mass spectrometry and tandem mass spectrometry of small oligonucleotides," 37th ASMS Conference on Mass Spectrometry and Allied Topics, May 21-26, Miami Beach, FL, pp. 844-845, 1989.
Jacobson et al., "Applications of mass spectrometry to DNA sequencing", GATA, 8(8):223-229, 1991.
Karas and Bahr, "Matrix-assisted laser desorption ionization mass spectrometry," Mass Spectrometry Reviews, 10:335-357, 1991.
Limbach et al., "Characterization of oligonucleotides and nucleic acids by mass spectrometry," Current Opinion Biotechnology, 6:96-102, 1995.
McNeal et al., "A new method for the analysis of fully protected oligonucleotides by .sup.252 Cf-plasma desorption mass spectrometry. 3. Positive ions," J. Am. Chem. Soc., 104:981-984, 1982.
Mizusawa et al., "Improvement of the dideoxy chain termination method of DNA sequencing by use of deoxy-7-deazaguanosine triphosphate in place of dGTP," Nucl. Acids Res., 14(3):1319-1325, 1986.
Mock et al., "Sample immobilization protocols for matrix assisted laser desorption mass spectrometry," The 40th ASMS Conference on Mass Spectrometry and Allied Topics, pp. 1921-1922, 1992.
Musser and Kelley, "Sensitivity enhancement for static and continuous flow FAB/MS analysis of nucleotides by quaternary amine surfactants," The 39th ASMS Conference on Mass Spectrometry and Allied Topics, pp. 374-375, 1989.
Nordhoff et al., "Matrix-assisted laser desorption/ionization mass spectrometry of nucleic acids with wavelengths in the ultraviolet and infrared," Rapid Comm. Mass Spectrometry, 6:771-776, 1992.
Overberg et al., "Laser desorption mass spectrometry, Part II performance and applications of matrix-assisted laser desorption/ionization of large biomolecules," Anal. Chem., 181-197, 1992.
Parr et al., "Matrix-assisted laser desorption/ionization mass spectrometry of synthetic oligodeoxyribonucleotides," Rapid Comm. Mass Spectrometry, 6:369-372, 1992.
Spengler et al., "Molecular weight determination of underivatized oligodeoxyribonucleotides by positive-ion matrix-assisted ultraviolet laser-desorption mass spectrometry," Rapid Comm. Mass Spectrometry, 4(4):99-102, 1990.
Stahl et al., "Solid phase DNA sequencing using the biotin-avidin system," Nucl. Acids Res., 16(7):3025-3039, 1988.
Stults and Marsters, "Characterization of oligodeoxynucleotide conjugates by electrospray ionization mass spectrometry," Proceedings of the 39th ASMS Conference on Mass Spectrometry and Allied Topics, May 19-24, Nashville, TN, pp. 1161-1162, 1991.
Stults and Marsters, "Improved electrospray ionization of synthetic oligodeoxynucleotides," Rapid Comm. Mass Spectrometry, 5:359-363, 1991.
Tong and Smith, "Solid-phase method for the purification of DNA sequencing reactions," Anal. Chem., 64:2672-2677, 1992.
Trainor, "DNA sequencing, automation, and the human genome," Anal. Chem., 62:418-426, 1990.
International Search Report dated Jan. 20, 1998(PCT/US 97/17101) (GETR:018P).
Sedlak, "Gene Trace Systems Bets its Future in Genomics on TOF Mass Spectroscopy," Genetic Engineering News, 16(21):, 1996. (website: http://www.genetrace.com).
Tang et al., "Detection of 500-Nucleotide DNA by Laser Desorption Mass Spectrometry," Rapid Commun. in Mass Spectrometry, 8(9):727-730, 1994.
Abrams, et al,. "Comprehensive Detection of Single Base Changes in Human Genomic DNA Using Denaturing Gradient Gel Electrophoresis and a GC Clamp," Genomics, 7:463-475, 1990.
Lee, et al., "DNA Sequencing with Dye-Labeled Terminators and T7 DNA Polymerase: Effect of Dyes and dNTPs on Incorporation of Dye-Terminators and Probability Analysis of Termination Fragments," Nucleic Acids Research, 20(10):2471-2483, 1992.
Mag, et al., "Synthesis and Selective Cleavage of an Oligodeoxynucleotide Containing a Bridged Internucleotide 5'-Phosphorothioate Linkage," Nucleic Acids Research, 19(7):1437-1441, 1991.
Orita, et al., "Detection of Polymorphisms of Human DNA by Gel Electrophoresis as Single-Strand Conformation Polymorphisms," Proc. Natl. Acad. Sci. USA, 86:2766-2770, 1989.
Pease, et al., "Light-Generated Oligonucleotide Arrays for Rapid DNA Sequence Analysis," Proc. Natl. Acad. Sci. USA, 91:5022-5026, 1994.
Richterich, et al., "Cytosine Specific DNA Sequencing with Hydrogen Peroxide," Nucleic Acids Research, 23(23):4922-4923, 1995.
Saleeba, et al., "Chemical Cleavage of Mismatch to Detect Mutations," Methods Enzymology, 217:286-295, 1993.
Sandaltzopoulos and Becker "Solid-Phase DNase I Footprinting," Biochemica, 4:25-27, 1995.
Shaler, et al., "Effect of Impurities on the Matrix-Assisted Laser Desorption Mass Spectra of Single-Stranded Oligodeoxynucleotides," Anal. Chem., 68(3):576-579, 1996.
Spengler, et al., "Laser Mass Analysis in Biology," Ber. Bunsenqes Phys. Chem., 93(3):396-402, 1989.
Szybalski, "Universal Restriction Endonucleases: Designing Novel Cleavage Specificities by Combining Adapter Oligodeoxynucleotide and Enzyme Moieties," Gene, 40:169-173, 1985.
Tanaka, et al., "Protein and Polymer Analyses up to m/z 100 000 by Laser Ionization Time-of-flight Mass Spectrometry," Rapid Commun. in Mass Spectrometry, 2:151-153, 1988.
Tang, et al., "Matrix-Assisted Laser Desorption/Ionization of Restriction Enzyme-Digested DNA," Rapid Commun. in Mass Spectrometry, 8:183-186, 1994.
Uhlmann and Peyman "Antisense Oligonucleotides: A New Therapeutic Principle," Chemical Reviews, 90(4):543-584, 1990.
Wang, et al., "DNA Sequencing from Single Phage Plaques Using Solid-Phase Magnetic Capture," BioTechniques, 18(1):130-135, 1995.
Wu, et al., "Matrix-Assisted Laser Desorption Time-of-Flight Mass Spectrometry of Oligonucleotides Using 3-Hydroxypicolinic Acid as an Ultraviolet-sensitive Matrix," Rapid Commun. in Mass Spectrometry, 7:142-146, 1993.
Youil, et al., "Screening for Mutations by Enzyme Mismatch Cleavage with T4 Endonuclease VII," Proc. Natl. Acad. Sci. USA, 92:87-91, 1995.
Bergh, et al., "Complete Sequencing of the p53 Gene Provides Prognostic Information in Breast Cancer Patients, Particularly in Relation to Adjuvant Systemic Therapy and Radiotherapy," Nature Medicine, 1:1029-1034, 1995.
Fang, et al., "Simultaneous Analysis of Mutant and Normal Alleles for Multiple Cystic Fibrosis Mutations by the Ligase Chain Reaction," Human Mutation, 6:144-151, 1995.
Bai, Jian, et al., "Procedures for Detection of DNA by Matrix-Assisted Laser Desorption/Ion
Becker Christopher Hank
Monforte Joseph Albert
Shaler Thomas Andrew
Tan Yuping
Campbell Eggerton A.
GeneTrace Systems Inc.
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