Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – X-ray contrast imaging agent
Patent
1997-09-12
1999-12-14
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
X-ray contrast imaging agent
424 945, 264 41, 427 214, 4272133, 42721331, A61K 4904, B01J 1302
Patent
active
060013338
ABSTRACT:
X-ray contrast media encapsulated within 50 nm to 10 .mu.m microspheres were shown to be a superior contrast agent for CT imaging of liver tumors. Use of the encapsulated agent resulted in significant improvement in the liver to tumor contrast ratio in CT images over prior art contrast media. The encapsulated media contrast also resulted in sustained contrast enhancement 1 hr after administration, providing the opportunity to use a lesser x-ray exposure in a single scan to discriminate cancerous tissue from normal surrounding tissue.
REFERENCES:
patent: 4616658 (1986-10-01), Shell et al.
patent: 4811741 (1989-03-01), Shell et al.
patent: 4865850 (1989-09-01), Shell et al.
patent: 5186922 (1993-02-01), Shell et al.
patent: 5658551 (1997-08-01), Schneidar et al.
patent: 5676928 (1997-10-01), Klaveness et al.
patent: 5811118 (1998-09-01), Ostro et al.
Seltzer, et al., "Biodistribution and Imaging Characteristics of lotrolan-Carrying Interdigitation-Fusion Vesicles," Investigative Radiology, vol. 26, S169-S176, Nov. Supplement, 1991.
Caride, et al, "Relaxation enhancement using liposomes carrying paramagnetic species," Magna Resonance Imaging 2(2): 107-12, 1984.
Kanke, et al., "Interaction of Microspheres with Blood Constituents. III. Macrophage Phagocytosis of Various Types of Polymeric Drug Carriers," Journal of Parenteral Science and Technology, 42: 157-65, 1988.
Kanke, et al., "Interaction of microspheres with blood constituents II: Uptake of biodegradabe particles by macrophages," Journal of Parenteral Science and Technolgy, 40: 114-8, 1986.
Kanke, et al., "Interaction of microspheres with blood constituents:I. Uptake of polystyrene spheres by monocytes and granulocytes and effect on immune responsiveness of lymphocytes," Journal of Parenteral Science and Technology, 37 (6): 210-7, 1983.
Navon, et al., "Liposomes containing paramagnetic macromolecules as MRI contrast agents," Magnetic Resonance in Medicine, 3(6): 876-80, 1986.
See, et al., Successful Immunization of Mice Using Liposomes Containing Inactivated, Prototype Strains of All Six Types of Coxsackievirus Group B Viruses, Vaccine Research, vol. 6, No. 1, 1997.
Seltzer, et al., Contrast Material--carrying Liposomes: Biodistribution, Clearance, and Imaging Characteristics, Radiology, Mar. 1995.
Stark et al., "Hepatic metastases: randomized, controlled comparison of detection with MR Imaging and CT." Radiology, 165: 399-406, 1987.
Unger, et al., "Liposomal Gd-DTPA effect of encapsulation of enhancement of hepatoma model by MRI," Magnetic Resonance Imaging, 7: 417-23, 1989.
Unger, et al., Hepatic metastases: Liposomal Gd-DTPA--enhanced MR Imaging, Radiology, 171, 81-5, 1989.
Dees Jos,e G.
Hartley Michael G.
Ram Michael J.
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